Results 71 to 80 of about 17,740,973 (321)
Media Supplementation With Gamma‐Oryzanol Improves the Outcome of Ovine Oocyte Maturation In Vitro
Veterinary Medicine and ScienceBackground The process of maturing ovine oocyte in vitro has not yet been raised with acceptable results. Objective This study was designed to evaluate the γ‐oryzanol effect as a supplement of maturation media on the development of ovine oocytes to ...
Saeed Musapoor +4 more
doaj +1 more source
MYBPC3 deficiency in cardiac fibroblasts drives their activation and contributes to fibrosis
Cell Death and Disease, 2022 Genetic mutations in the MYBPC3 gene encoding cardiac myosin binding protein C (cMyBP-C) are the most common cause of hypertrophic cardiomyopathy (HCM). Myocardial fibrosis (MF) plays a critical role in the development of HCM.
Xiaodong Zou +7 more
doaj +1 more source
Formation of giant planets and brown dwarfs on wide orbits [PDF]
, 2013 Context: We studied numerically the formation of giant planet (GP) and brown dwarf (BD) embryos in gravitationally unstable protostellar disks and compared our findings with directly-imaged, wide-orbit (>= 50 AU) companions known to-date. The viability of the disk fragmentation scenario for the formation of wide-orbit companions in protostellar disks ...
arxiv +1 more source
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Development and validation of deep learning based embryo selection across multiple days of transfer [PDF]
arXiv, 2022 This work describes the development and validation of a fully automated deep learning model, iDAScore v2.0, for the evaluation of embryos incubated for 2, 3, and 5 or more days. The model is trained and evaluated on an extensive and diverse dataset including 181,428 embryos from 22 IVF clinics across the world.
arxiv
Interplay of integrins and selectins in metastasis
Molecular Oncology, EarlyView.Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva +2 more
wiley +1 more source
Optimization of Buffalo (Bubalus bubalis) Embryonic Stem Cell Culture System
Cell Journal, 2015 Objective: In order to retain an undifferentiated pluripotent state, embryonic stem (ES) cells have to be cultured on feeder cell layers. However, use of feeder layers limits stem cell research, since experimental data may result from a combined ES ...
Mohammad Zandi +7 more
doaj
Destroying unwanted embryos in research [PDF]
EMBO reports, 2009 Some of the human embryos generated by in vitro fertilization (IVF) are treasured by the couples whose gametes were fused to create them; they may fulfil the wish of the prospective parents to have a child. We call these ‘wanted embryos’. It would be wrong to destroy such embryos in research; however, not all embryos are wanted.
Douglas, T, Savulescu, J
openaire +4 more sources
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source