Results 81 to 90 of about 279,297 (287)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Rethinking Human Embryo Research Policies. [PDF]

Hastings Cent Rep, 2021
Matthews KRW, Iltis AS, Marquez NG, Wagner DS, Robert JS, de Melo-Martín I, Bigg M, Franklin S, Holm S, Metzler I, Molè MA, Taupitz J, Testa G, Sugarman J.   +13 more
europepmc   +1 more source

Factors associated with willingness to donate embryos for research among couples undergoing IVF [PDF]

, 2015
Catarina Samorinha, Mílton Severo, Elisabete Alves, Helena Machado, Bárbara Figueiredo, Susana Silva   +5 more
openalex   +1 more source

New guidelines for stem cell and embryo research from the ISSCR [PDF]

, 2021
Eric Anthony, Robin Lovell‐Badge, Sean J. Morrison   +2 more
openalex   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Human embryo research, stem cell-derived embryo models and in vitro gametogenesis: Considerations leading to the revised ISSCR guidelines. [PDF]

Stem Cell Reports, 2021
Clark AT, Brivanlou A, Fu J, Kato K, Mathews D, Niakan KK, Rivron N, Saitou M, Surani A, Tang F, Rossant J.   +10 more
europepmc   +1 more source

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

Comparison of the 2021 International Society for Stem Cell Research (ISSCR) guidelines for "laboratory-based human stem cell research, embryo research, and related research activities" and the corresponding Japanese regulations. [PDF]

Regen Ther, 2022
Yui H, Muto K, Yashiro Y, Watanabe S, Kiya Y, Kamisato A, Inoue Y, Yamagata Z.   +7 more
europepmc   +1 more source

Zebrafish Embryo as an Emerging Model Organism in Neurodevelopmental Toxicity Research

, 2021
Salim Çalışkan, Ebru Emekli‐Alturfan   +1 more
openalex   +1 more source

Research progress in the role of non-coding RNAs and embryo implantation. [PDF]

, 2023
Lin Liu, Jiayi Guo, Wenxin Gao, Mengmeng Gao, Xiaoling Ma   +4 more
openalex   +1 more source