Results 221 to 230 of about 187,086 (335)

From Invaginating Site to Deep Lesion: Spatial Transcriptomics Unravels Ectopic Endometrial Penetration Features in Adenomyosis

open access: yesAdvanced Science, EarlyView.
This work utilizes spatial transcriptomics to map the transcriptional landscape of adenomyosis with obvious invagination structure from the invaginating site to deep lesions. By integrating with single‐cell RNA sequencing, this study elucidates the molecular features of invagination, invasion, and fibrosis, and finds the major participants and vital ...
Boyu Li   +19 more
wiley   +1 more source

Prediction of clinical pregnancy after frozen embryo transfer based on ultrasound radiomics: an analysis based on the optimal periendometrial zone. [PDF]

open access: yesBMC Pregnancy Childbirth
Xu F   +11 more
europepmc   +1 more source

The Novel Dual GIP and GLP‐1 Receptor Agonist Tirzepatide Attenuates Colon Cancer Development by Regulating Glucose Metabolism

open access: yesAdvanced Science, EarlyView.
Tirzepatide, a dual GIP/GLP‐1 receptor agonist for diabetes, suppresses colorectal cancer growth by targeting glucose metabolism. It inhibits cancer cell proliferation, promotes apoptosis, and induces tumor regression. It reduces glucose uptake and destabilizes HIF‐1α for degradation to downregulate PFKFB3/PFK‐1 enzymes, thus contributing to the ...
Yikai Zhang   +11 more
wiley   +1 more source

Speaking up for the safety of the children following frozen embryo transfer. [PDF]

open access: yesHum Reprod Open
Pinborg A   +5 more
europepmc   +1 more source

Loss of Golga7 Suppresses Oncogenic Nras‐Driven Leukemogenesis without Detectable Toxicity in Adult Mice

open access: yesAdvanced Science, EarlyView.
NRAS mutations are widespread in hematologic malignancies. Our study shows that GOLGA7 serves as a safe and effective therapeutic target for NRAS‐driven leukemia. Loss of Golga7 in adult mice effectively suppresses NrasG12D‐driven myeloproliferative neoplasm by disrupting its PM localization and impairing subsequent MAPK signaling, without affecting ...
Bo Jiao   +18 more
wiley   +1 more source

Endometrial injection of embryo culture supernatant adversely affects assisted reproductive technology outcomes in frozen thawed embryo transfer cycles. [PDF]

open access: yesSci Rep
Ito A   +15 more
europepmc   +1 more source

Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU‐EMRE Assembly

open access: yesAdvanced Science, EarlyView.
Berberine, a safe and FDA‐approved drug, is identified as a novel mitochondrial calcium uniporter (MCU) inhibitor. By disrupting MCU‐EMRE interaction, Berberine prevents mitochondrial calcium overload and protects against ischemia/reperfusion injury, offering a promising therapeutic strategy for diseases linked to mitochondrial calcium dysregulation ...
Haixin Zhao   +17 more
wiley   +1 more source

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