SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang +17 more
wiley +1 more source
Correction to "Extracellular vesicle-LncRNA HOTAIR modulates esophageal cancer chemoresistance and immune microenvironment via miR-375/CDH2 pathway". [PDF]
europepmc +1 more source
Correction: Sobeh et al. <i>Haematoxylon campechianum</i> Extract Ameliorates Neuropathic Pain via Inhibition of NF-κB/TNF-α/NOX/iNOS Signalling Pathway in a Rat Model of Chronic Constriction Injury. <i>Biomolecules</i> 2020, <i>10</i>, 386. [PDF]
Sobeh M +8 more
europepmc +1 more source
Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su +10 more
wiley +1 more source
Reframing gastric lymph nodes as a parapancreatic lymph chain: an embryology-driven rationale for omento-bursectomy and omentum-preserving gastrectomy to facilitate safe infrapyloric lymph node dissection. [PDF]
Tokuhara T +3 more
europepmc +1 more source
A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang +15 more
wiley +1 more source
Ten Years After the Warnock Report: Is the Human Neo-Conceptus a Person? [PDF]
Sutton, Agneta
core +1 more source
Correction: Wasik et al. Correlation Between Periostin Expression and Pro-Angiogenic Factors in Non-Small-Cell Lung Carcinoma. <i>Cells</i> 2024, <i>13</i>, 1406. [PDF]
Wasik A +6 more
europepmc +1 more source

