Results 211 to 220 of about 65,434 (266)

KRT14 Drives Basal Muscle‐Invasive Bladder Cancer Progression and Lung Metastasis by Directly Binding to and Stabilizing IGF2BP1

Advanced Science, EarlyView.
We identified a Krt14+ Igf2bp1+ bladder cancer population linked to EMT. Mechanistically, KRT14 stabilizes and transports IGF2BP1 to invasive protrusions, initiating a positive feedback loop that drives metastasis and poor outcomes. ABSTRACT Basal‐type muscle‐invasive bladder cancer (BMIBC) is characterized by aggressive metastasis and poor prognosis ...
Shirui Huang, Zhihan Zhou, Qipeng Xie, Zheng Wang, Lijiong He, Yutong Liu, Lijuan Huang, Liuxian Ye, Limeng Hu, Baokun Li, Yang Wang, Xiaohui Hua, Xuelei Liu, Yunping Zhao, Jingxia Li, Jinfei Chen, Guiying Wang, Xian Shen, Wei Chen, Chuanshu Huang   +19 more
wiley   +1 more source

Correction: Integrated spectroscopic and morphological analyses reveal cellular shifts in gene-silenced melanoma CSCs. [PDF]

Sci Rep
Ozdil B, Güler G, Ataman E, Aktug H.
europepmc   +1 more source

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

Editorial: Biomarker discovery and validation in neurological diseases. [PDF]

Front Cell Neurosci
Singla S, Vaidya B, Martínez-Palma L, Hermann DM.   +3 more
europepmc   +1 more source

Hair Follicle Seedling Cryomicroneedles from Hierarchical Microfluidic Organoid on a Chip

Advanced Science, EarlyView.
In this paper, a hierarchical microfluidic chip is developed to produce uniform hair follicle organoids (HFOs) in cryomicroneedles. Cryopreservation agents encapsulate HFOs, preserving viability and hair growth potential. The cryomicroneedles enable simple intradermal transplantation with good skin penetration.
Xinyue Cao, Dongyu Xu, Minhui Lu, Yuanjin Zhao   +3 more
wiley   +1 more source

Author Correction: Extracellular vesicle-based targeted protein degradation platform for multiple extracellular proteins. [PDF]

EMBO Mol Med
Tong B, Zhang X, Zhu D, Wang Y, Wei J, Ou Z, Liang H, Xu H, Zhang Z, Lei J, Zhou X, Wu D, Song Y, Wang K, Feng X, Tan L, Liao Z, Yang C.   +17 more
europepmc   +1 more source

Play to learn: innovating embryology education through a web-based gamification platform, and evaluating its effects on medical students' reaction, learning, and behavior. [PDF]

BMC Med Educ
Rahimipour M, Haghjoo R, Mosalanejad L, Karimian Z.   +3 more
europepmc   +1 more source

Correction: Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy. [PDF]

Mol Cancer
Angelopoulou A, Theocharous G, Valakos D, Polyzou A, Magkouta S, Myrianthopoulos V, Havaki S, Fiorillo M, Tremi I, Vachlas K, Nisotakis T, Thanos DF, Pantazaki A, Kletsas D, Bartek J, Petty R, Thanos D, McCrimmon RJ, Papaspyropoulos A, Gorgoulis VG.   +19 more
europepmc   +1 more source

Correction: Mitochondrial Transplantation Therapy for Ischemic Stroke: Progress and Challenges. [PDF]

Cell Mol Neurobiol
Zhao ZH, Yang XL, Lu ZW, Li T, Zhao LL, Li Y, Dang MJ, Zhang GL, Chen K, Fan H.   +9 more
europepmc   +1 more source