Results 41 to 50 of about 151,621 (342)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
From bench to in silico and backwards: What have we done on genetics of recurrent pregnancy loss and implantation failure and where should we go next? [PDF]
Genetics and Molecular BiologyHuman reproduction goes through many challenges to its success and in many cases it fails. Cases of pregnancy loss are common outcomes for pregnancies, and implantation failures (IF) are common in assisted reproduction attempts.
Flavia Gobetti Gomes +10 more
doaj +1 more source
Plants, 2023 Satureja pilosa Velen., S. coerulea Janka and S. kitaibelii Wierzb. ex Heuff. are Balkan endemic species, and they are distributed in restricted territories, primarily found in dry grasslands, rocky slopes, and stony habitats.
Ivanka Semerdjieva +4 more
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Condensing embryology teaching for medical students: can it be taught in 2 hours?
Advances in Medical Education and Practice, 2017 Fawz Kazzazi, Jonathan Bartlett School of Clinical Medicine, University of Cambridge, Cambridge, UK Introduction: Embryology forms a valuable part of the medical school curriculum. However, medical students traditionally struggle with revising embryology
Kazzazi F, Bartlett J
doaj
Branchial cleft cysts : a pictorial review [PDF]
, 2018 Cystic masses of the neck may represent a wide variety of pathological conditions. Among these, branchial anomalies are the commonest paediatric congenital lesions of the head and neck.
core +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Праці Наукового товариства імені Шевченка. Медичні науки, 2018 “HISTOLOGY, CYTOLOGY, EMBRYOLOGY” AS EDITED BY O. D. LUTSYK AND Y.B.
Volodymyr Rybalchenko
doaj
Indian Journal of Plastic Surgery, 2021 This review describes the Story of the Human Hand. It traces the functional needs that led to evolution of the human hand as well as its embryological development.
Sunil M. Thirkannad, Rahul Patil
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source