Results 51 to 60 of about 142,714 (291)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
REASONS FOR DIFFICULT TOPICS IN ANATOMY AND THEIR SOLUTIONS AS PER UNDERGRADUATE MEDICAL STUDENTS
Khyber Medical University Journal, 2021 OBJECTIVE: To identify the topics difficult to understand in learning Anatomy and to investigate the reasons of difficulty and their possible solutions.
Khadija Qamar +4 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Condensing embryology teaching for medical students: can it be taught in 2 hours?
Advances in Medical Education and Practice, 2017 Fawz Kazzazi, Jonathan Bartlett School of Clinical Medicine, University of Cambridge, Cambridge, UK Introduction: Embryology forms a valuable part of the medical school curriculum. However, medical students traditionally struggle with revising embryology
Kazzazi F, Bartlett J
doaj
SurgeriesEmbryological development of the vascular system consists of growth and regression of developing vessels, often resulting in numerous variations. This cadaveric case report describes an individual with a duplicated inferior vena cava accompanied by ...
Vishnu Bharani +2 more
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Quantitative Experimental Embryology: A Modern Classical Approach
Journal of Developmental Biology, 2022 Experimental Embryology is often referred to as a classical approach of developmental biology that has been to some extent replaced by the introduction of molecular biology and genetic techniques to the field. Inspired by the combination of this approach
Lara Busby +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Праці Наукового товариства імені Шевченка. Медичні науки, 2018 “HISTOLOGY, CYTOLOGY, EMBRYOLOGY” AS EDITED BY O. D. LUTSYK AND Y.B.
Volodymyr Rybalchenko
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From Development To Evolution: The Re-Establishment Of The Alexander Kowalevsky Medal [PDF]
, 2002 The Saint Petersburg Society of Naturalists has reinstated the Alexander O. Kowalevsky Medal. This article announces the winners of the first medals and briefly reviews the achievements of A.O.
Gilbert, Scott F., Mikhailov, A. T.
core +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source