Results 71 to 80 of about 254,687 (310)

Endoderm Generates Endothelial Cells during Liver Development

Stem Cell Reports, 2014
Organogenesis requires expansion of the embryonic vascular plexus that migrates into developing organs through a process called angiogenesis. Mesodermal progenitors are thought to derive endothelial cells (ECs) that contribute to both embryonic ...
Orit Goldman, Songyan Han, Wissam Hamou, Vanina Jodon de Villeroche, Georges Uzan, Heiko Lickert, Valerie Gouon-Evans   +6 more
doaj   +1 more source

Fertilization and normal embryonic and early fetal development

, 2021
The anatomy and physiology of placental and embryonic development is a field where medicine exerts its greatest impact on early pregnancy at present time, and it opens fascinating aspects of embryonic differentiation. Clinical assessment of those stages of growth relies heavily on three-dimensional (3D) and four-dimensional (4D) sonography, one of the ...
Asim Kurjak, Ritsuko K. Pooh, Aida Salihagic-Kadic, Iva Lausin, Lara Spalldi-Barisic   +4 more
openaire   +2 more sources

The generation of live offspring from vitrified oocytes [PDF]

, 2011
Oocyte cryopreservation is extremely beneficial for assisted reproductive technologies, the treatment of infertility and biotechnology and offers a viable alternative to embryo freezing and ovarian grafting approaches for the generation of embryonic stem
Sanchez-Partida, Luis, Sumer, Huseyin, Sumer, H, Kelly, Richard, Lo, Camden, Kelly, RDW, Aharon, R, Moira K. O'Bryan, Kelly Richard D. W., Michael K. Holland, Camden Y. Lo, O'Bryan Moira K., St. John, Justin C., Justin C St John, Camden Y Lo, St John, Justin C., L. Gabriel Sanchez-Partida, Sumner, Huseyin, Sanchez-Partida L. Gabriel, John St., JC, St John, Justin, Sanchez-Partida, L. Gabriel, Richard D W Kelly, Michael K Holland, Moira K O'Bryan, St. John Justin C., Aharon Rotem, Sumer Huseyin, Lo Camden Y., Holland, Michael K., O'Bryan, Moira K., Rotem Aharon, Aharon, Rotem, Justin C. St. John, Holland Michael K., Sanchez-Partida, LG, O'Bryan, Moira, Lo, CY, Holland, MK, Lo, Camden Y., Huseyin Sumer, L Gabriel Sanchez-Partida, Richard D. W. Kelly, Kelly, Richard D. W., Sanchez-Partilda, L. Gabriel, O'Bryan, MK, Holland, Michael   +46 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Protocol for In Utero Fetal-to-Fetal Kidney Transplantation in Rats

Bio-Protocol
Congenital renal disorders, such as the Potter sequence, result from renal dysgenesis. To explore a prenatal therapeutic approach for fetuses with kidney insufficiency, we established an in utero transplantation protocol using donor fetal kidneys ...
Keita Morimoto, Shuichiro Yamanaka, Takashi Yokoo   +2 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates [PDF]

, 2015
Fetal growth is determined by the feto-placental genome interacting with the maternal in utero environment. Failure of this interplay leads to poor placental development and fetal growth restriction (FGR), which is associated with future metabolic ...
Lowe, R, Williams, DJ, Rakyan, V, Hitman, GA, Mathews, C, Hillman, SL, Finer, S, Smart, MC, Rakyan, VK   +8 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Exploring polyamines: Functions in embryo/fetal development

Animal Nutrition, 2017
Polyamines such as putrescine, spermidine, spermine and agmatine are aliphatic polycationic compounds present in all living cells, and are derived from amino acids, intestinal bacteria, exfoliated enterocytes and supported from diet.
Tarique Hussain, Bi'e Tan, Wenkai Ren, Najma Rahu, Dildar Hussain Kalhoro, Yulong Yin   +5 more
doaj   +1 more source

Mice Lacking Hbp1 Function Are Viable and Fertile. [PDF]

PLoS ONE, 2017
Fetal germ cell development is tightly regulated by the somatic cell environment, and is characterised by cell cycle states that differ between XY and XX gonads.
Cassy M Spiller, Dagmar Wilhelm, David A Jans, Josephine Bowles, Peter Koopman   +4 more
doaj   +1 more source