Results 61 to 70 of about 417,774 (313)

Effect of the extract of the Plectranthus barbatus (Andr.) Benth in the reproductive performance of Rattus novergicus (Berkenhout, 1769) [PDF]

Biotemas, 2007
The supposed use of the extract from Plectranthus barbatus for abortive purposes motivated this investigation about the possible toxic effects of ‘False-boldo’ on the embryos and on the offspring of female Wistar rats. Twenty-seven females and nine males,
Gisélida Maria Baquini da Silva, Cinthia Cardoso Rodrigues, Thelma Duarte Delgado Brandolt, Sandro Márcio Nunes Ferrão   +3 more
doaj  

Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C.elegans Embryos [PDF]

, 2015
During cell division, chromatin alternates between a condensed state to facilitate chromosome segregation and a decondensed form when DNA replicates.
Blow, J. Julian; id_orcid, Karim Labib, Craig, Gillian, Remi Sonneville, Labib, Karim, Sonneville, Remi, Gillian Craig, Anton Gartner, J. Julian Blow, Blow, J. Julian, Labib, Karim; id_orcid, Gartner, Anton   +11 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Embryo futures and stem cell research: The management of informed uncertainty [PDF]

, 2011
This article is available open access and is distributed under a Creative Commons license (http://creativecommons.org/licenses/by/3.0/). Copyright @ 2011 The Authors.In the social worlds of assisted conception and stem cell science, uncertainties ...
Williams, C, Clare Williams, Kathryn Ehrich (16049615), Kathryn Ehrich, Bobbie Farsides, Bobbie Farsides (4461928), Rosamund Scott, Scott, R, Rosamund Scott (16049618), Farsides, Bobbie, Ehrich, K, Ehrich, Kathryn, Williams, Clare, Clare Williams (14068554), Farsides, B, Scott, Rosamund   +15 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Ensoulment and IVF Embryos

, 1987
This paper examines the metaphysical question of 'ensoulment' in relation to the theory, put forward in an earlier paper, that human life begins when the newly formed body organs and systems of the embryo begin to function as an organised whole, at which
Shea, Moira C., Shea, M.C.
core   +1 more source

Consent agreements for cryopreserved embryos : the case for choice [PDF]

, 2010
Under current UK law, an embryo cannot be transferred to a woman’s uterus without the consent of both of its genetic parents, that is both of the people from whose gametes the embryo was created.
Sheldon, S., Sozou, P.D., Hartshorne, G.M., Sozou, Peter D., Hartshorne, G., Sozou, Peter D, Hartshorne, Geraldine M, Hartshorne, Geraldine M., Sheldon, Sally, Sozou, P.   +9 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Negotiating Meanings About Embryos in Australia: From Potential Humans to Prohibited Substances

, 2011
In the late 1990s, human embryonic stem-cell research became a highly emotional and politicized debate. In 2001, the United States announced a ban on all federal funding for research involving human embryos, and other countries around the world were ...
Harvey, Olivia
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source