Results 231 to 240 of about 1,408,830 (315)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

#Emergence

, 2019
Dawson, Paul ; https://orcid.org/
core   +1 more source

Rising bedaquiline resistance: exploring potential causes and next steps. [PDF]

Eur Respir J
Schildkraut JA, Flood D, Sloan DJ, Heinrich N, Fox S, Lange C, Wells C, Tiberi S.   +7 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Integrated noninvasive biomarkers for identifying esophageal variceal bleeding and optimizing risk stratification

Asian Journal of Surgery
Shuo Zhang, Tomohiko Akahoshi, Tomoharu Yoshizumi, Masatoshi Eto   +3 more
doaj   +1 more source

A safer airway strategy during induction and emergence: laryngeal mask airway versus face mask in pediatric rigid bronchoscopy. [PDF]

Crit Care
Liu Z, Wei L, Xie Y, Yu L, Liu Y, Zhao J.   +5 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Effects of High Temperature on Development, Survival, and Antioxidant Responses of Immature <i>Monolepta hieroglyphica</i>. [PDF]

Insects
Shi R, Lou J, Zhen D, Kou J, Wang Q, Liu C, Yang Q.   +6 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Prevention of Recurrent Cases of Emergence Delirium in Electroconvulsive Therapy. [PDF]

Cureus
Saeed MI, Kjærgård Hansen CK, Jørgensen A, Baandrup L.   +3 more
europepmc   +1 more source