Results 111 to 120 of about 1,905,338 (418)

Retrospective Study of Midazolam Protocol for Prehospital Behavioral Emergencies [PDF]

open access: yes, 2020
Introduction: Agitated patients in the prehospital setting pose challenges for both patient care and emergency medical services (EMS) provider safety. Midazolam is frequently used to control agitation in the emergency department setting; however, limited
Huebinger, Ryan M.   +7 more
core   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

open access: yesMolecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Epidemic Intelligence Threat Reporting Profile in Portugal during the COVID-19: 2 Years of Decrease in Reporting on Non-COVID-19 Threats

open access: yesPortuguese Journal of Public Health
Background: Epidemic intelligence (EI) ensures early detection, assessment, and communication of public health threats. Threat reporting defines priorities and mobilize resources for surveillance, prevention, and control.
Vasco Ricoca Peixoto   +7 more
doaj   +1 more source

Ready or Not? Protecting the Public's Health in the Age of Bioterrorism, 2004 [PDF]

open access: yes, 2004
Examines ten key indicators to evaluate state preparedness to respond to bioterrorist attacks and other public health emergencies.
Laura M. Segal   +3 more
core  

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

As Below, So Before: `Synchronic' and `Diachronic' Conceptions of Spacetime Emergence [PDF]

open access: yesarXiv, 2019
Typically, a less fundamental theory, or structure, emerging from a more fundamental one is an example of synchronic emergence. A model (and the physical state it describes) emerging from a prior model (state) upon which it nevertheless depends is an example of diachronic emergence.
arxiv  

Incoherent? No, Just Decoherent: How Quantum Many Worlds Emerge [PDF]

open access: yesPhilosophy of Science. 2024: 91, 288-309
The modern Everett interpretation of quantum mechanics describes an emergent multiverse. The goal of this paper is to provide a perspicuous characterisation of how the multiverse emerges making use of a recent account of (weak) ontological emergence. This will be cashed out with a case study that identifies decoherence as the mechanism for emergence ...
arxiv   +1 more source

Complex natural disasters and the role of the university [PDF]

open access: yes, 2010
This repository item contains a single issue of Issues in Brief, a series of policy briefs that began publishing in 2008 by the Boston University Frederick S. Pardee Center for the Study of the Longer-Range Future.What is the potential and future role of
Silva, Enrique
core   +1 more source

Establishment and biological characterization of radioresistant colorectal cancer cell lines

open access: yesFEBS Open Bio, EarlyView.
Under ionizing radiation exposure, radiation‐sensitive cancer cells exhibit oxidative stress and DNA damage, while radiation‐resistant cancer cells exhibit strong antioxidant properties and DNA damage repair. Radiotherapy resistance is a major cause of recurrence and metastasis in colorectal cancer (CRC).
Tian‐Yin Qu   +10 more
wiley   +1 more source

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