Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Continental scale geographic analysis of hospital exposure to natural hazards in the Americas
Scientific ReportsNatural hazards—including earthquakes, hurricanes, floods, landslides, and volcanic activity—pose substantial threats to healthcare systems in the Americas. This study aims to evaluate the exposure of primary, secondary, and tertiary hospitals across the
Leonardo Hernandez +9 more
doaj +1 more source
Emergency egress requirements for caution and warning, logistics, maintenance, and assembly stage MB-6 of Space Station Freedom [PDF]
The safety and survival of the crewmembers has been the prime concern of NASA. Previous studies have been conducted mainly for emergencies occurring during the operating mode of the fully assembled Station. The present study was conducted to evaluate the
Ray, Paul S.
core +1 more source
Evaluating the effectiveness of the Emergency Neurological Life Support educational framework in low-income countries. [PDF]
, 2018 BackgroundThe Emergency Neurological Life Support (ENLS) is an educational initiative designed to improve the acute management of neurological injuries. However, the applicability of the course in low-income countries in unknown.
Acharya, Subhash +6 more
core +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Progress on International Health Regulations (2005) core capacities in WHO's Western Pacific Region
Western Pacific Surveillance and ResponseThe International Health Regulations (2005; IHR) are a legally binding instrument for the 196 States Parties, including the 194 Member States of the World Health Organization (WHO), requiring them to build and maintain capacities across critical domains ...
Kai Xiao +6 more
doaj +1 more source
Verbal De-escalation of the Agitated Patient: Consensus Statement of the American Association for Emergency Psychiatry Project BETA De-escalation Workgroup [PDF]
, 2012 Janet S. Richmond +7 more
openalex +1 more source
Causal Emergence and Epiphenomenal Emergence [PDF]
Erkenntnis, 2018 According to one conception of strong emergence, strongly emergent properties are nomologically necessitated by their base properties and have novel causal powers relative to them. In this paper, I raise a difficulty for this conception of strong emergence, arguing that these two features (i.e., nomological necessitation and causal novelty) are ...
openaire +2 more sources
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Early and late complications of bariatric operation. [PDF]
, 2018 Weight loss surgery is one of the fastest growing segments of the surgical discipline. As with all medical procedures, postoperative complications will occur. Acute care surgeons need to be familiar with the common problems and their management. Although
Beekley, Alec +3 more
core +1 more source