Results 81 to 90 of about 290,252 (310)
BMC Public HealthBackground The international health emergency caused by the emergence of the SARS-CoV-2 virus demonstrated the expanding usefulness of multi-country disease outbreak information gathered through event-based surveillance (EBS) as an extension beyond the ...
C. J. McKnight +2 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Institutionalizing Gender in Emergencies: Case study of Pakistan
, 2017 This case study describes implementation of the project Institutionalizing Gender in Emergencies: Bridging Policy and Practice. The project, supported by ECHO Enhanced Response Capacity and Oxfam, was implemented by Oxfam in Pakistan between September ...
Avis, Steph +3 more
core +1 more source
Continental scale geographic analysis of hospital exposure to natural hazards in the Americas
Scientific ReportsNatural hazards—including earthquakes, hurricanes, floods, landslides, and volcanic activity—pose substantial threats to healthcare systems in the Americas. This study aims to evaluate the exposure of primary, secondary, and tertiary hospitals across the
Leonardo Hernandez +9 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Progress on International Health Regulations (2005) core capacities in WHO's Western Pacific Region
Western Pacific Surveillance and ResponseThe International Health Regulations (2005; IHR) are a legally binding instrument for the 196 States Parties, including the 194 Member States of the World Health Organization (WHO), requiring them to build and maintain capacities across critical domains ...
Kai Xiao +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Histamine-Mediated Emergencies
, 2012 The wheel and flare of urticaria is the pathognomonic feature of histamine-mediated cutaneous lesions. In fact, urticaria is one of the most common chief complaints encountered by dermatologists.
Rosen, Alyx +5 more
core +1 more source