Results 141 to 150 of about 2,872,967 (366)

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

De novo synthesis of short‐chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys

FEBS Open Bio, EarlyView.
The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley   +1 more source

Retracted: A Study on the Relationship between Sense of Disease Uncertainty and Family Strength and Mental Resilience in Guardians of Children with Inflammatory Bowel Disease

Emergency Medicine International, 2023
Emergency Medicine International
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Emergency response ICT systems [PDF]

, 2014
This audit assessed how Information and Communications Technology systems and processes are used to deliver an emergency service response. Overview Victorians rely on emergency services organisations during emergencies and crisis incidents, and expect ...

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Letter of Concern from the Association of Academic Chairs of Emergency Medicine Regarding ACGME Proposed Changes [PDF]

This letter, signed by over 50 academic chairs of emergency medicine, urges the ACGME to reconsider a proposed mandate requiring all emergency medicine residency programs to adopt a four-year training model.
Seaberg, David, Smith, Ben C, Volturo, Gregory A, Wyatt, Thomas E, Baumann, Michael, Corbin, Theodore J, Dhindsa, Harinder S, Berkeley, Ross P, Schwartz, Adam, Gonzalez Sanchez, Juan A, Johnson, David, Stowell, Jeffrey R, Emerman, Charles L, Farcy, David A, Hoek, Terry Vanden, Pauzé, Denis R, Rodi, Scott W, Gibbs, Michael A, Michelson, Edward A, Chansky, Michael E, Fox, Chris, Hoyle, John D, Hamilton, Richard J, Algren, D Adam, Kurz, Michael Christopher, Miller, Chadwick, Pang, Peter S, McCormack, Robert F, Jehle, Dietrich, Squillante, Marc D, Knapp, Barry J, Yealy, Donald M, Thomas, J Jeremy, Goode, Christopher S, Godwin, Steven Andy, Keim, Samuel M, Sklar, David P, Shiver, Stephen A, Nugent, Andrew, Riviello, Ralph J, Wolfe, Richard E, Paolo, William F, Walters, E Lea, Becker, Lance B, O'Neil, Brian J, Cannon, Chad M, Overton, David T, Perez, Amanda L, McNamara, Robert, Norse, Ashley, Khazaeni, Babak, Caffery, Terrell S, Panacek, Edward A, Arnold, Thomas, Hawthorne, Clint, Leibner, Evan   +55 more
core   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Retracted: Clinical Evaluation of Unilateral Vertebroplasty for OVCF

Emergency Medicine International, 2023
Emergency Medicine International
doaj   +1 more source

Kansas Division of Emergency Management [PDF]

application/pdf; "Building sustainable capabilities across all phases of Emergency Management in Kansas through selfless service..
Kansas. Division of Emergency Management.
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