Results 31 to 40 of about 998,753 (312)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

A retrospective analysis of time delays in patients presenting with stroke to an academic emergency department

South African Journal of Radiology, 2018
Background: Stroke presents commonly to the emergency department (ED), and is a common cause of morbidity and mortality in South Africa. Early ED presentation and early neuroimaging are required in order for thrombolysis to be a potential therapeutic ...
Diteboho Khalema, Lara N. Goldstein, Susan Lucas   +2 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Clinical Findings of Patients with Dental Emergencies

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: Some patients need emergency dental care and people with low economic status are more likely to go to hospital emergency departments.
Avideh Maboudi, Mehdi Taghiyan, Reza Ali Mohammadpour, Nafisesadat Mirshahvalad, Hamed Aminiahidashti   +4 more
doaj  

The use of a new automatic device for patients' assessment at Triage in Emergency Department

Emergency Care Journal, 2013
Objectives: To assess time saving in an Emergency Department arising out of the introduction of automatic devices (Carescape™ V100) to measure vital signs compared to the manual devices.
Salvatore Di Somma, Enrico Ferri, Caterina Tranne, Daniele De Nuzzo, Daniele Salvatori, Benedetta De Bernardinis, Chiara Serena Gori   +6 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Emergency Room Consultations: Problems and Solutions

Eurasian Journal of Emergency Medicine, 2015
Aim: This study aimed at identifying the problems of consultations requested from the emergency department (ED), the solution to these problems, suggestions for physicians to reveal the nature of the issue addressed, and to contribute to the literature ...
Halil İbrahim Çıkrıklar, Yusuf Yürümez, İbrahim Keleş, Şerife Özdinç, Fatih Selvi, Zülfü Engindeniz, Ramazan Kuşarslan, Murat Yücel, Mehmet Ali Ekici, Canan Baydemir   +9 more
doaj   +1 more source

Follow Up for Emergency Department Patients After Intravenous Contrast and Risk of Nephropathy

Western Journal of Emergency Medicine, 2014
Introduction: Contrast-induced nephropathy (CIN), defined as an increase in serum creatinine (SCr) greater than 25% or ≥0.5 mg/dL within 3 days of intravenous (IV) contrast administration in the absence of an alternative cause, is the third most common ...
Getaw Worku Hassen, Albert Hwang, Lydia Liyun Liu, Felicia Mualim, Toshiro Sembo, Ting Jia Tu, Daniel Hsiang Wei, Paul Johnston, Ana Costea, Carlos Meletiche, Shakeel Usmani, Andre Barber, Rajnish Jaiswal, Hossein Kalantari   +13 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source