Results 51 to 60 of about 8,173,709 (257)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Retrospective evaluation of urological admissions to emergency service of a training and research hospital

Urology Research and Practice, 2019
Objective: Many patients consult emergency services with urological complaints. The aim of this study was to investigate the epidemiology, clinical presentation and treatments of urological emergency cases in a training and research hospital ...
Ramazan Topaktaş, Selçuk Altın, Cemil Aydın, Ali Akkoç, Yakup Yılmaz   +4 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Gender Differences in Acute and Chronic Pain in the Emergency Department: Results of the 2014 Academic Emergency Medicine Consensus Conference Pain Section. [PDF]

, 2014
Pain is a leading public health problem in the United States, with an annual economic burden of more than $630 billion, and is one of the most common reasons that individuals seek emergency department (ED) care.
Tsze, Daniel S., Patel, Roma G, Keefe, Francis J., Fillingim, Roger B, Dorai, Suprina, Chang, Andrew K, Keefe, Francis J, Platts-Mills, Timothy F, Peak, David A, Fillingim, Roger B., Engel, Kirsten, Musey, Paul I, Safdar, Basmah, Rosenau, Alexander M, DO, Rosenberg, Mark, Musey, Paul I., Chang, Andrew K., Tsze, Daniel S, Rosenau, Alex, Miner, James R., Fusaro, Angela M., Bijur, Polly, Engel, Kirsten G, Patel, Roma G., Lee, David C, Safdar, Basmah, MD, Engel, Kirsten G., Nam, Catherine S, Bortsov, Andrey V, Dorai, Suprina, MD, McLean, Samuel A, Linnstaedt, Sarah D., McLean, Samuel A., Linnstaedt, Sarah D, Platts-Mills, Timothy F., Feldman, James A, Feldman, James A., Lee, David C., Fusaro, Angela M, Nam, Catherine S., Miner, James R, MD, Bortsov, Andrey V., Peak, David A., Miner, J. R., Musey, Paul, Fillingim, R. B., Patel, R. G., McLean, S. A., Musey, P. I., Linnstaedt, S. D., Nam, C. S., Lee, D. C., McLean, Samuel, Bortsov, A. V., +12 additional authors, Platts-Mills, T. F.   +55 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Patient perceptions of diagnostic certainty at discharge and patient satisfaction in the emergency department

, 2021
We investigated one critical factor that may influence patients’ subjective experience (and, in turn, satisfaction): perceived diagnostic certainty—or the extent to which patients leave the emergency department (ED) feeling certain they know what caused ...
Hagerty, Serena F, Barasz, Kate, Burke, Ryan C, Smulowitz, Peter B, Isbell, Linda M   +4 more
core   +1 more source

Emergency department patients' perception of care: do doctors understand their patients? [PDF]

, 2011
Includes abstract.Includes bibliographical references (leaves 42-55).The aim of my study is to directly compare the patient’s perceptions of care received in the emergency department to that of the attending physician’s.
Mahomed, Zeyn
core   +1 more source