Results 71 to 80 of about 8,173,709 (257)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Other title: Title from ODPS Ohio Emergency Management Agency newsletters home page: Ohio's emergency management news

, 2008
Biweekly, May 25, 2007-Sept. 29, 2008.; Weekly, -May 11, 2007.; Electronic coverage as of Sept. 5, 2014: Vol. 3, no. 1 (Jan. 6, 2006)-v. 5, no. 17 (Sept. 29, 2008); "A publication of the Ohio Emergency Management Agency, a division of the Ohio Department
Ohio Emergency Management Agency.
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Reducing attendances and waits in emergency departments : a systematic review of present innovations [PDF]

, 2004
Reducing the waits in emergency departments is important for patients and is a government priority. In order to reduce waits the whole system must be considered.
McLeod, Eileen, Szczepura, Ala, Walley, Paul, Fisher, Joanne, Wilson, Sue, Dale, Jeremy, Cooke, Matthew   +6 more
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Boarding of critically Ill patients in the emergency department [PDF]

, 2020
ObjectivesEmergency department boarding is the practice of caring for admitted patients in the emergency department after hospital admission, and boarding has been a growing problem in the United States.
Brian T. Wessman, Rudy, Susanna, Zachary Ginsberg, Susanna Rudy, Kyle Gunnerson, Mohr, Nicholas M, Mohr, Nicholas M., Bridgette Kram, Emlet, Lillian L, Marie‐Carmelle Elie‐Turenne, Wessman, Brian T., Marie-Carmelle Elie-Turenne, Gunnerson, Kyle, Kevin M. Jones, Wessman, Brian T, Ginsberg, Zachary, Elie-Turenne, Marie-Carmelle, Lillian L. Emlet, Jones, Kevin M., Bassin, Benjamin, Ellender, Timothy, Marcolini, Evie, Evie Marcolini, Elie‐turenne, Marie‐carmelle, Timothy Ellender, Nicholas M. Mohr, Benjamin Bassin, Emlet, Lillian L., Jones, Kevin M, Kram, Bridgette   +29 more
core   +1 more source

Depression Is Associated with Repeat Emergency Department Visits in Patients with Non-specific Abdominal Pain

Western Journal of Emergency Medicine, 2014
Introduction: Patients with abdominal pain often return multiple times despite no definitive diagnosis. Our objective was to determine if repeat emergency department (ED) use among patients with non-specific abdominal pain might be associated with a ...
Andrew Charles Meltzer, Benjamin Bregman, Janice Blanchard   +2 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Emergency department crowding increases 10-day mortality for non-critical patients: a retrospective observational study

, 2023
The current evidence suggests that higher levels of crowding in the Emergency Department (ED) have a negative impact on patient outcomes, including mortality.
Huhtala, Heini, Anna Eidstø, Jari Ylä-Mattila, Ari Palomäki, Ylä-Mattila, Jari, Koivistoinen, Teemu, Teemu Koivistoinen, Tuominen, Jalmari, Palomäki, Ari, Eidstø, Anna, Jalmari Tuominen, Heini Huhtala   +11 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Readiness to Change and Reasons for Intended Reduction of Alcohol Consumption in Emergency Department versus Trauma Population

Western Journal of Emergency Medicine, 2014
Introduction: The primary objective was to identify the most common reasons for intending to cut back on alcohol use, in emergency department (ED) and trauma patient populations.
Craig Harrison, Wirachin Hoonpongsimanont, Craig L. Anderson, Samer Roumani, Jie Weiss, Bharath Chakravarthy, Shahram Lotfipour   +6 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source