Results 51 to 60 of about 4,390,126 (313)

The Geriatric ED: Structure, Patient Care, and Considerations for the Emergency Department Geriatric Unit

International Journal of Gerontology, 2014
The emergency department (ED) is a unique medical care environment with many challenges. Aging populations increasingly use the ED as an acute and chronic treatment site given the accessibility and resources inherent to emergency provider staff.
John H. Burton, Janet Young, Carol A. Bernier   +2 more
doaj   +1 more source

Computer assisted assessment and advice for "non-serious" 999 ambulance service callers : the potential impact on ambulance despatch [PDF]

, 2003
Objective: To investigate the potential impact for ambulance services of telephone assessment and triage for callers who present with non-serious problems (Category C calls) as classified by ambulance service call takers.
Crouch, R., Dale, Jeremy, Foster, T., George, S., Glucksman, E., Hartley-Sharpe, C., Higgins, J., Hooper, R., Snooks, Helen, Williams, S.   +9 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Emergency department visits in older patients: a population-based survey

BMC Emergency Medicine, 2019
BackgroundGiven the higher incidence of emergency conditions in older inhabitants, the global increase in aged population will pose a challenge for emergency services.
M. Ukkonen, E. Jämsen, R. Zeitlin, Satu-Liisa K. Pauniaho   +3 more
semanticscholar   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Emergency Department Departures: Untangling the Complexities of Early Exits in a Large Italian region

Epidemiology, Biostatistics and Public Health
Leaving Emergency Departments (ED) early is an important failure of these structures, constituting a risk for the health of the people who renounce the benefits of such healthcare, and a cost to the countries that finance healthcare service for their ...
Vincenzo Alfano, Alessandro Scaletti
doaj   +1 more source

Wireless E911 Emergency Communications Fund Iowa Homeland Security and Emergency Management Division of the Iowa Department of Public Defense independent auditor's reports, basic financial statements and supplementary information, June 30, 2009. [PDF]

, 2010
Audit report on the Wireless E911 Emergency Communication Fund of the Iowa Homeland Security and Emergency Management Division of the Iowa Department of Public Defense for the year ended June 30 ...

core  

Trends in US Emergency Department Use After Sexual Assault, 2006-2019 [PDF]

, 2022
Emily L. Vogt, Charley Jiang, Quinton S. Jenkins, Maya J. Millette, Martina T. Caldwell, Kathleen Mehari, Erica E. Marsh   +6 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source