Results 41 to 50 of about 172,829 (264)

The Effects of Topical Ketamine in Reducing Venipuncture Pain

مجله دانشکده پزشکی اصفهان, 2019
Background: Different pharmacological methods have been introduced for managing venipuncture pain. The aim of this study was to evaluate the effect of topical ketamine in reducing the pain of venipuncture.
Farhad Heydari, Sanaz Khalilian, Keihan Golshani, Saeed Majidinejad, Babak Masoumi   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Management Patterns of Croup in Korean Emergency Departments: A Nationwide Cohort Study

Children
Background: Despite the established importance of prescribing steroids to children with croup, many physicians in Korean emergency departments (EDs) do not adhere to this recommendation.
Jin Hee Kim, Jae Yun Jung, Soyun Hwang, Joong Wan Park, Eui Jun Lee, Ha Ni Lee, Do Kyun Kim, Young Ho Kwak   +7 more
doaj   +1 more source

Predictability of the emergency department triage system during the COVID-19 pandemic [PDF]

Clinical and Experimental Emergency Medicine
Objective Emergency department (ED) triage systems are used to classify the severity and urgency of emergency patients, and Korean medical institutions use the Korean Triage and Acuity Scale (KTAS). During the COVID-19 pandemic, appropriate treatment for
Se Young Oh, Ji Hwan Lee, Min Joung Kim, Dong Ryul Ko, Hyun Soo Chung, Incheol Park, Jinwoo Myung   +6 more
doaj   +1 more source

Addressing overcrowding in an emergency department: an approach for identifying and treating influential factors and a real-life application

Israel Journal of Health Policy Research, 2020
Background Overcrowding in hospital emergency departments that arises from long length-of-stay is an unfortunate common occurrence. While some factors affecting length-of-stay are well known, there may be additional factors that have not yet been ...
Guy Wachtel, Amir Elalouf
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Process flows of an emergency department. How process modelling and simulation can help improve the efficiency and quality of patient care [PDF]

SHS Web of Conferences
Emergency departments are the first point of contact for life-saving care worldwide. Despite this importance in patient care, emergency departments face a number of shortcomings. For example, emergency departments have been struggling for many years with
Angler Yannik, Loßin Astrid, Goetz Olav
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source