Results 81 to 90 of about 8,194 (251)

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Passivation‐Induced Species Dynamics and Microstructural Evolution in Solid‐State Lithium–Sulfur Cathodes

Advanced Science, EarlyView.
The formation of insulating Li2S during discharge in solid‐state lithium–sulfur batteries passivate reaction sites and limits sulfur utilization. In this work, a microstructure‐resolved modeling framework coupling transport and reaction kinetics is developed to predict charge–discharge behavior and reveal particle‐scale species evolution and incomplete
Arpan K. Sharma, Bairav S. Vishnugopi, Elif Pınar Alsaç, Matthew T. McDowell, Partha P. Mukherjee   +4 more
wiley   +1 more source

Criteria codes for unrecognized stroke/TIA patients by Emergency Medical Services dispatchers in Copenhagen, Denmark

BMC Emergency Medicine
Background Early diagnosis is essential in stroke treatment. Medical dispatchers play a key role in ensuring quick assessment, transport, and treatment of stroke patients by recognizing stroke symptoms.
Philip Busch Andreasen, Jonathan Wenstrup, Stig Nikolaj Fasmer Blomberg, Christina Kruuse, Helle Collatz Christensen   +4 more
doaj   +1 more source

Impact of drone-specific dispatch instructions on the safety and efficacy of drone-delivered emergency medical treatments: A randomized simulation pilot study

Resuscitation Plus
Introduction: Medical drones have potential for improving the response times to out-of-hospital emergencies. However, widespread adoption is hindered by unanswered questions surrounding medical dispatch and bystander safety.
Emma E. Davidson, Jason A Correll, Adam Gottula, Laura R. Hopson, Thomas B Leith, Noor K. Majhail, Emily J. Mathias, James M Pribble, Nathan B. Roberts, Isabella G. Scott, James A. Cranford, Nathaniel Hunt, Christine M. Brent   +12 more
doaj   +1 more source

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

Atomic Defects in Layered Transition Metal Dichalcogenides for Sustainable Energy Storage and the Intelligent Trends in Data Analytics

Advanced Science, EarlyView.
This review comprehensively summarizes the atomic defects in TMDs for their applications in sustainable energy storage devices, along with the latest progress in ML methodologies for high‐throughput TEM data analysis, offering insights on how ML‐empowered microscopy facilitates bridging structure–property correlation and inspires knowledge for precise ...
Zheng Luo, Ying Yang, Zizhen Fu, Fengqi Liu, Susu Fang, Kele Xu, Shanshan Wang   +6 more
wiley   +1 more source

Asymmetric Mass Transport in Polybromide Ionic Liquids and Its Impact on Dual‐Plating Zinc Bromine Batteries

Advanced Science, EarlyView.
This study elucidates mass transport dynamics within polybromide ionic liquids in dual‐plating zinc–bromine batteries using operando impedance spectroscopy. The findings reveal that sluggish polybromide transport during dissolution contrasts with rapid bromide transport during charging.
Sung Il Kim, Kyungjae Shin, Heejung Kang, Seok Hee Han, Hee‐Tak Kim, Taek Dong Chung   +5 more
wiley   +1 more source

Ion‐Confinement‐Assisted Erasure Purifies Oxidized MXene for Reuse

Advanced Science, EarlyView.
An erasure‐purification strategy removes surface‐derived TiO2 from oxidized Ti3C2Tx MXene by ion‐confinement‐induced interfacial conversion to soluble titanates, followed by brief acid washing. The scalable process enables approximately 70% material recovery, restores electrical conductivity, and recovers functional performance, including high ...
Xuefeng Zhang, Yujia Wu, Huayu Xu, Jinyi Ye, Yanfang Yang, Haohan Wu, Jiayi Lu, Hao Li, Dongxiao Kan, Jingfeng Wang, Hui Kang, Zhimin Fan   +11 more
wiley   +1 more source

Outpatient care in acute and prehospital emergency medicine by emergency medical and patient transport service over a 10-year period: a retrospective study based on dispatch data from a German emergency medical dispatch centre (OFF-RESCUE). [PDF]

BMC Emerg Med, 2021
Schehadat MS, Scherer G, Groneberg DA, Kaps M, Bendels MHK.   +4 more
europepmc   +1 more source

A Functionality‐Graded Cathode Electrolyte Interphase Enables Ultra‐Long Cycling Stability in Aqueous Zn–Mn Batteries

Advanced Science, EarlyView.
Through the interfacial reaction of KH2PO4, a functionally graded CEI with hydrated, organic, and inorganic layers is constructed. This suppresses interfacial water corrosion, mitigates volume stress, and promotes charge carrier transport, achieving superior battery stability.
Kaisheng Sun, Yanlei Geng, Shengen Gong, Fangfei Li, Liang Li, Xiaoteng Jia, Danming Chao, Caiyun Wang   +7 more
wiley   +1 more source