Results 171 to 180 of about 10,370,996 (312)

Bioengineered Stroma‐Camouflaged Nanovesicles Disrupt the IDO1/CD276 Immunosuppressive Circuit to Reinvigorate Antitumor Immunity

Advanced Science, EarlyView.
Bioengineered stroma‐camouflaged nanovesicles (AM@UIO‐BMS/DOX) convert the immunosuppressive tumor niche into an immunoresponsive milieu by disrupting the IDO1/CD276 circuit. Anti‐CD276 membrane camouflage guides tumor accumulation and deep penetration, enabling controlled co‐delivery of DOX and the IDO1 inhibitor BMS‐986205.
Ziqi Zhang, Jing Luo, Mengdi Zhang, Jingying Zhuang, Yating Zheng, Yang Zhang, Zhihong Huang, Xinhua Lin, Shuzhen Xu, Hong Yao, Gang Liu, Bing Chen   +11 more
wiley   +1 more source

Other title: State of Connecticut Department of Emergency Services and Public Protection; Other title: Emergency Services and Public Protection

, 2015
Updated irregularly; Began in 2012.; Title from home page (publisher's Web site, viewed Feb. 9, 2012).; At head of title: State of Connecticut .; Harvested from the web on 4/18/15Official website of the Connecticut Department of Emergency Services and ...

core  

Modeling IN out-of-hospital emergency medical services-a scoping review of approaches and applications. [PDF]

Front Public Health
Zahorka F, Strauss C, Schmid M, Wallentin G, Dahlmann P.   +4 more
europepmc   +1 more source

Targeting Nupr1‐Mediated p53 Mitochondrial Sequestration Alleviates Aortic Dissection by Restoring the Gadd45b‐Dependent Survival Program

Advanced Science, EarlyView.
This study identifies Nupr1 as a crucial stress‐responsive orchestrator driving AD. Under severe stress, Nupr1 massively accumulates within mitochondria to sequester p53, triggering apoptosis and concurrently repressing the Gadd45b‐mediated survival program.
Xi Yang, Ke‐Yuan Chen, Yue Tian, Zong‐Sheng Jiang, Jian Lei, Xing‐Hui Zhuang, Jiang‐Bin Wu, Le‐Le Tang, Hao‐Yu Li, Xiao‐Hui Chen, Yue Wang, Yu‐Mei Li, Zhi‐Huang Qiu, Zi‐Wen Cai, Liang‐Wan Chen   +14 more
wiley   +1 more source

Emergency Medical Services Systems [PDF]

Prehospital and Disaster Medicine, 2006
openaire   +2 more sources

Other title: State of Connecticut Department of Emergency Services and Public Protection; Other title: Emergency Services and Public Protection

, 2016
Updated irregularly; Began in 2012.; Title from home page (publisher's Web site, viewed Feb. 9, 2012).; At head of title: State of Connecticut .; Harvested from the web on 4/14/16Official website of the Connecticut Department of Emergency Services and ...

core  

Prehospital Transfusion With Red Blood Cells and Fresh Plasma in Helicopter Emergency Medical Services. [PDF]

Acta Anaesthesiol Scand
Andersen JB, Risgaard B, Schou R, Dahl M, Hansen TM, Johansson PI, Erikstrup C, Steinmetz J, Fenger-Eriksen C.   +8 more
europepmc   +1 more source

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

Advanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo, Katie Shi, Lina Kafadarian, Alexandra Bermudez, Johnny Diaz, Liam Edwards, Yunqi Hong, Ziyi Chen, Hyeonji Hwang, Weihong Yan, Alan Levinson, Robert Damoiseaux, Cho‐Jui Hsieh, Tanya Stoyanova, Andrew S. Goldstein, Neil Y.C. Lin   +15 more
wiley   +1 more source

Nuciferine Suppresses Inflammatory Hepatocarcinogenesis by Targeting cPLA2‐Dependent Arachidonic Acid Metabolism

Advanced Science, EarlyView.
Nuciferine directly binds the C2 domain of cPLA2, impairing its Ca2+‐dependent membrane translocation and activation. By suppressing arachidonic acid release and downstream pro‐inflammatory eicosanoid production, nuciferine attenuates NF‐κB signaling and inflammatory hepatocarcinogenesis, revealing cPLA2 as a direct molecular target underlying its ...
Jing Sun, Xinyan Wu, Shuwei Luo, Yilang Liu, Jie Liu, Jun Lu, Weimin Wang, Xiao Feng, Tuo Zhang, Dipak Panigrahy, Jianjun Deng, Xiaojun Liao, Haixia Yang   +12 more
wiley   +1 more source

Public-private partnerships for UAV-assisted emergency medical services in aging communities: an evolutionary game approach. [PDF]

Front Public Health
Zhong J, Gao Y.
europepmc   +1 more source