Results 61 to 70 of about 6,249,641 (297)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Rapid Extrication versus the Kendrick Extrication Device (KED): Comparison of Techniques Used After Motor Vehicle Collisions

Western Journal of Emergency Medicine, 2015
Introduction: The goal of this study was to compare application of the Kendrick Extrication Device (KED) versus rapid extrication (RE) by emergency medical service personnel.
Bucher, Joshua, Dos Santos, Frank , Frazier, Danny , Merlin, Mark   +3 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

First responder airway and compression rate cluster randomized controlled trial: rational and design

Resuscitation Plus
Background: The specific components of professional first-responder CPR (chest compressions and ventilations) are associated with clinical outcomes following out-of-hospital cardiac arrest (OHCA).
Thomas Rea, Jenny Shin, Jennifer Blackwood, Catherine Counts, Sam Sharar, David L. Murphy, Andrew McCoy, Andrew Latimer, Nicholas J. Johnson, Peter J. Kudenchuk, Michael Sayre, Siobhan Brown, Robert Schmicker, Susanne May   +13 more
doaj   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Patient safety attitudes and their predictors among emergency healthcare providers in a military medical city in the Kingdom of Saudi Arabia: a cross-sectional study

Frontiers in Medicine
BackgroundThe increase in the number of patient safety incidents poses a challenge for hospital management. Various studies have been conducted on the safety of patients in healthcare settings, but gaps exist concerning the attitude of healthcare ...
Adel Saeed S. Alotaibi, Adel Saeed S. Alotaibi, Salem Ali S. Alshehri, Salem Ali S. Alshehri, Naif H. Alanazi, Abdualrahman S. Alshehry, Homood A. Alharbi, Abdulmajeed Wadid A. Alanazi, Ali Ahmed M. Alkhalaf, Gerlynn C. Tumala, Abdulaziz Moadi B. Alotaibi, Mohammed Ahmed Alfaifi, Regie B. Tumala   +12 more
doaj   +1 more source

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto, Umberto Pensato, Ilaria Casetta, Giorgio U. Marcello, Angelo Barra, Anna Poggesi, Edoardo Carlesi, Sara Mancini, Andrea Ginestroni, Vittorio Miele, Alessandro Padovani, Andrea Morotti, Enrico Fainardi   +12 more
wiley   +1 more source

Leslie Asher, Emergency Medical Technician

, 1978
Leslie Asher, emergency medical technician, sits inside an ...

core  

Emergency Medical Technician Dies In Ambulance Crash - New York [PDF]

On July 13, 2001, a 27-year-old female Emergency Medical Technician (EMT) [the victim] died when the ambulance she was working in struck a support column for an elevated train track.

core   +1 more source