Results 71 to 80 of about 5,967,174 (297)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Transportation of patines from the offices [PDF]

ABC: časopis urgentne medicine, 2019
Introduction: City Institute for Emergency Medicine Belgrade provides 24 hours a day health care for citizens, both in the fieldwork and inside its offices of the Central building.
Ranđelović Simona N., Živanović Slavoljub R.   +1 more
doaj  

Rapid Extrication versus the Kendrick Extrication Device (KED): Comparison of Techniques Used After Motor Vehicle Collisions

Western Journal of Emergency Medicine, 2015
Introduction: The goal of this study was to compare application of the Kendrick Extrication Device (KED) versus rapid extrication (RE) by emergency medical service personnel.
Bucher, Joshua, Dos Santos, Frank , Frazier, Danny , Merlin, Mark   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Validity and risk factor analysis for helicopter emergency medical services in Japan: a pilot study

BMC Emergency Medicine, 2021
Background Some emergency departments use triage scales, such as the Canadian Triage and Acuity Scale and Japan Urgent Stroke Triage Score, to detect life-threatening situations.
Noriaki Yamada, Yuichiro Kitagawa, Takahiro Yoshida, Sho Nachi, Hideshi Okada, Shinji Ogura   +5 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

First responder airway and compression rate cluster randomized controlled trial: rational and design

Resuscitation Plus
Background: The specific components of professional first-responder CPR (chest compressions and ventilations) are associated with clinical outcomes following out-of-hospital cardiac arrest (OHCA).
Thomas Rea, Jenny Shin, Jennifer Blackwood, Catherine Counts, Sam Sharar, David L. Murphy, Andrew McCoy, Andrew Latimer, Nicholas J. Johnson, Peter J. Kudenchuk, Michael Sayre, Siobhan Brown, Robert Schmicker, Susanne May   +13 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Patient safety attitudes and their predictors among emergency healthcare providers in a military medical city in the Kingdom of Saudi Arabia: a cross-sectional study

Frontiers in Medicine
BackgroundThe increase in the number of patient safety incidents poses a challenge for hospital management. Various studies have been conducted on the safety of patients in healthcare settings, but gaps exist concerning the attitude of healthcare ...
Adel Saeed S. Alotaibi, Adel Saeed S. Alotaibi, Salem Ali S. Alshehri, Salem Ali S. Alshehri, Naif H. Alanazi, Abdualrahman S. Alshehry, Homood A. Alharbi, Abdulmajeed Wadid A. Alanazi, Ali Ahmed M. Alkhalaf, Gerlynn C. Tumala, Abdulaziz Moadi B. Alotaibi, Mohammed Ahmed Alfaifi, Regie B. Tumala   +12 more
doaj   +1 more source