Results 21 to 30 of about 4,140,192 (302)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Paediatric emergency medicine [PDF]

Journal of Paediatrics and Child Health, 2016
Background: Intranasal (IN) fentanyl provides rapid and powerful non-parenteral analgesia in the ED. A concentrated solution of fentanyl (300 mg/mL) has been used in prior trials, yet many ED use the standard solution at a concentration of 50 mg/mL, which is widely available and of low cost.
Starr, M, Babl, F, Isaacs, D
openaire   +3 more sources

Emergency Medicine [PDF]

, 2023
To better understand and prioritize research on emergency care for Veterans, the Department of Veteran Affairs (VA) Health Services Research and Development convened the 16th State of the Art Conference on VA Emergency Medicine (SAVE) in Winter 2022 with
Anita A. Vashi, Timko, Christine, Hastings, S. Nicole, Chen, Jason I., Kristin Mattocks, Mattocks, Kristin, Ula Hwang, Dawn M. Bravata, Bravata, Dawn M., Christine Timko, S. Nicole Hastings, Michael J. Ward, Abel, Erica A., Vashi, Anita A., Jason I. Chen, Hwang, Ula, Erica A. Abel, Ward, Michael J.   +17 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Procedures in emergency medicine: oropharyngeal airway insertion

, 2013
This video is part of a series of videos demonstrating common procedures performed in the Emergency Medicine setting. It was prepared by Cape Town Emergency Medicine's consultants and registrars. This short simulated video demonstrates the technique of
Oosthuizen, Almero, Cape Town Emergency Medicine Registrars   +1 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Emergency Medicine Milestones [PDF]

Journal of Graduate Medical Education, 2013
Michael S. Beeson, MD, MBA, is Residency Program Director in the Department of Emergency Medicine, Akron General Medical Center; Wallace A. Carter, MD, is Residency Program Director in the Department of Emergency Medicine, New York Presbyterian Hospital; Theodore A.
Michael S, Beeson, Wallace A, Carter, Theodore A, Christopher, Jonathan W, Heidt, James H, Jones, Lynne E, Meyer, Susan B, Promes, Kevin G, Rodgers, Philip H, Shayne, Mary Jo, Wagner, Susan R, Swing   +10 more
openaire   +2 more sources

Wellness: Combating Burnout and Its Consequences in Emergency Medicine [PDF]

, 2020
Medicine recognizes burnout as a threat to quality patient care and physician quality of life. This issue exists throughout medicine but is notably prevalent in emergency medicine (EM). Because the concept of “wellness” lacks a clear definition, attempts
Kellogg, Adam R., Kellogg, Adam, Purpura, Andrea, Stehman, Christine R., Clark, Ryan L.   +4 more
core   +1 more source