Results 31 to 40 of about 4,990,220 (301)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Procedures in emergency medicine: needle cricothyroidotomy

, 2013
This video is part of a series of videos demonstrating common procedures performed in the Emergency Medicine setting. It was prepared by Cape Town Emergency Medicine's consultants and registrars.
Oosthuizen, Almero, Cape Town Emergency Medicine Registrars   +1 more
core   +1 more source

Gender Differences in Acute and Chronic Pain in the Emergency Department: Results of the 2014 Academic Emergency Medicine Consensus Conference Pain Section. [PDF]

, 2014
Pain is a leading public health problem in the United States, with an annual economic burden of more than $630 billion, and is one of the most common reasons that individuals seek emergency department (ED) care.
Tsze, Daniel S., Patel, Roma G, Keefe, Francis J., Fillingim, Roger B, Dorai, Suprina, Chang, Andrew K, Keefe, Francis J, Platts-Mills, Timothy F, Peak, David A, Fillingim, Roger B., Engel, Kirsten, Musey, Paul I, Safdar, Basmah, Rosenau, Alexander M, DO, Rosenberg, Mark, Musey, Paul I., Chang, Andrew K., Tsze, Daniel S, Rosenau, Alex, Miner, James R., Fusaro, Angela M., Bijur, Polly, Engel, Kirsten G, Patel, Roma G., Lee, David C, Safdar, Basmah, MD, Engel, Kirsten G., Nam, Catherine S, Bortsov, Andrey V, Dorai, Suprina, MD, McLean, Samuel A, Linnstaedt, Sarah D., McLean, Samuel A., Linnstaedt, Sarah D, Platts-Mills, Timothy F., Feldman, James A, Feldman, James A., Lee, David C., Fusaro, Angela M, Nam, Catherine S., Miner, James R, MD, Bortsov, Andrey V., Peak, David A., Miner, J. R., Musey, Paul, Fillingim, R. B., Patel, R. G., McLean, S. A., Musey, P. I., Linnstaedt, S. D., Nam, C. S., Lee, D. C., McLean, Samuel, Bortsov, A. V., +12 additional authors, Platts-Mills, T. F.   +55 more
core   +1 more source

Overcoming barriers to promotion for women and underrepresented in medicine faculty in academic emergency medicine

, 2021
Equity in the promotion of women and underrepresented minorities (URiM) is essential for the advancement of academic emergency medicine and the specialty as a whole. Forward‐thinking healthcare organizations can best position themselves to optimally care
Oh, Laura, Greene, Andrea L., Judith A. Linden, Sheryl L. Heron, Ankur A. Doshi, Doshi, Ankur A., Lo, Bruce, Jordana Haber, Finnell, John T., Ava E. Pierce, Andrea L. Greene, Zeidan, Amy, Bisan Salhi, Christopher Sampson, Battaglioli, Nicole J., Linden, Judith A., Nicole Franks, Fisher, Jonathan, Haber, Jordana, Pillow, M. Tyson, Nicole J. Battaglioli, John T. Finnell, Lema, Penelope C., Bruce Lo, Salhi, Bisan, Laura Oh, Penelope C. Lema, Lall, Michelle D., Sandra L. Werner, Pierce, Ava E., Michelle D. Lall,, Amy Zeidan, Sampson, Christopher, Heron, Sheryl L., Franks, Nicole, Jonathan Fisher, M. Tyson Pillow, Werner, Sandra L.   +37 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Emergency Medicine

World Journal of Advanced Research and Reviews
Emergency defines the potential provision of rapid and effective Medical Nursing Care, in situations where life is threatened. Emergency medicine is defined as the branch of Medicine that operates within an organized EMS. Emergency Medicine System (EMS) is defined as the organized set of provision of immediate pre-hospital, in-hospital and inter ...
openaire   +4 more sources

Hyperbaric medicine in emergencies

Vojnosanitetski pregled, 2008
<zakljucak> Imajuci u vidu mali broj kontraindikacija, primena HBOT od velike je koristi u zbrinjavanju urgentnih stanja, narocito u kombinaciji sa hirurskim i medikamentnim procedurama. .
Rabrenović Milorad, Matunović Radomir, Rabrenović Violeta, Todorović Veljko, Mićević Dušan, Zoranović Uroš   +5 more
openaire   +3 more sources

Procedures in emergency medicine: surgical cricothyroidotomy

, 2013
This video is part of a series of videos demonstrating common procedures performed in the Emergency Medicine setting. It was prepared by Cape Town Emergency Medicine's consultants and registrars.
Oosthuizen, Almero, Cape Town Emergency Medicine Registrars   +1 more
core   +1 more source