Results 31 to 40 of about 1,535,745 (364)

L&D in the ED: A Game-Based Approach to Learning High-Risk Obstetric Emergencies. [PDF]

open access: yes, 2019
IntroductionTeaching emergency medicine residents the principles of obstetric emergencies is a challenging task, as these emergencies are uncommon in general practice and include specific maneuvers for difficult and precipitous deliveries.
Chen, Esther H, Silverio, Luz M
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

The Role of Emergency Medicine Specialist on Performance of the Emergency Department of Kerman Shahid Bahonar Hospital: A Qualitative Study [PDF]

open access: yes, 2016
The Role of Emergency Medicine Specialist on Performance of the Emergency Department of Kerman Shahid Bahonar Hospital: A Qualitative Study Ghorbani Nia Rahil1*, Amiresmaeili MohammadReza2, NekoeiMoghadam Mahamod3, Saberi Nia Amin4 1.
Amiresmaeili, MohammadReza   +3 more
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Farewell to a Friend - with "Love" [PDF]

open access: yes, 2020
Peter Rosen, MD, FAAEM, one of the main founding fathers and mothers in the field of emergency medicine, passed away in Tucson, Arizona, on the 11th of November 2019 from complications of chronic diseases, with his best friend and wife Ann at his side ...
Kazzi, Amin
core  

Application of Big Data in Decision Making for Emergency Healthcare Management [PDF]

open access: yes, 2018
Application of big data in healthcare has enhanced efficiency and decision making. This is of critical benefit to patients, healthcare professionals and the healthcare institution.
Leung, Kelvin Tak Yiu, Stevenson, Anne
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Obstacles and Challenges to Implementing Multi-departmental QI at a Large, Academic Training Center-Lessons Learned from a HCV Screening Program [PDF]

open access: yes, 2017
Objectives: We aimed to double the HCV screening rate of ‘baby-boomers’ admitted to the medicine teaching service at Methodist Hospital over the course of 6 months and demonstrate improved linkage to care for HCV RNA+ individuals. Initial efforts were a
Arastu, MD, S.   +6 more
core   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

open access: yes
Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra   +9 more
wiley   +1 more source

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