Results 51 to 60 of about 4,140,192 (302)
USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra +16 morewiley +1 more sourceOvercoming barriers to promotion for women and underrepresented in medicine faculty in academic emergency medicine
, 2021 Equity in the promotion of women and underrepresented minorities (URiM) is essential for the advancement of academic emergency medicine and the specialty as a whole. Forward‐thinking healthcare organizations can best position themselves to optimally care Oh, Laura, Greene, Andrea L., Judith A. Linden, Sheryl L. Heron, Ankur A. Doshi, Doshi, Ankur A., Lo, Bruce, Jordana Haber, Finnell, John T., Ava E. Pierce, Andrea L. Greene, Zeidan, Amy, Bisan Salhi, Christopher Sampson, Battaglioli, Nicole J., Linden, Judith A., Nicole Franks, Fisher, Jonathan, Haber, Jordana, Pillow, M. Tyson, Nicole J. Battaglioli, John T. Finnell, Lema, Penelope C., Bruce Lo, Salhi, Bisan, Laura Oh, Penelope C. Lema, Lall, Michelle D., Sandra L. Werner, Pierce, Ava E., Michelle D. Lall,, Amy Zeidan, Sampson, Christopher, Heron, Sheryl L., Franks, Nicole, Jonathan Fisher, M. Tyson Pillow, Werner, Sandra L. +37 morecore +1 more sourceA novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz +9 morewiley +1 more sourceAccident and emergency medicine or emergency medicine? [PDF]
Emergency Medicine Journal, 1999 C Reid, B Watts, J Nicholas, S Slack, K Hartington, M Howell, A Okwonko, N Robinson, G L Cumberbatch, H Simpson, A Stearman, E Ivory, D Wakely, H Vecht, S Brady +14 more +7 more sourcesExploring Gender Bias in Nursing Evaluations of Emergency Medicine Residents [PDF]
, 2019 Objectives
Nursing evaluations are an important component of residents’ professional development as nurses are present for interactions with patients and nonphysician providers.Pettit, Katie, Megan M. Palmer, Nash Whitaker, Morgan, Zachary S., Brucker, Krista, Whitaker, Nash, Erynn Thinnes, Krista Brucker, Thinnes, Erynn, Banta, Alison M., Palmer, Megan M., Katie Pettit, Alison M. Banta, Zachary S. Morgan +13 morecore +1 more sourceIn vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer +8 morewiley +1 more sourceGender Differences in Acute and Chronic Pain in the Emergency Department: Results of the 2014 Academic Emergency Medicine Consensus Conference Pain Section. [PDF]
, 2014 Pain is a leading public health problem in the United States, with an annual economic burden of more than $630 billion, and is one of the most common reasons that individuals seek emergency department (ED) care.Tsze, Daniel S., Patel, Roma G, Keefe, Francis J., Fillingim, Roger B, Dorai, Suprina, Chang, Andrew K, Keefe, Francis J, Platts-Mills, Timothy F, Peak, David A, Fillingim, Roger B., Engel, Kirsten, Musey, Paul I, Safdar, Basmah, Rosenau, Alexander M, DO, Rosenberg, Mark, Musey, Paul I., Chang, Andrew K., Tsze, Daniel S, Rosenau, Alex, Miner, James R., Fusaro, Angela M., Bijur, Polly, Engel, Kirsten G, Patel, Roma G., Lee, David C, Safdar, Basmah, MD, Engel, Kirsten G., Nam, Catherine S, Bortsov, Andrey V, Dorai, Suprina, MD, McLean, Samuel A, Linnstaedt, Sarah D., McLean, Samuel A., Linnstaedt, Sarah D, Platts-Mills, Timothy F., Feldman, James A, Feldman, James A., Lee, David C., Fusaro, Angela M, Nam, Catherine S., Miner, James R, MD, Bortsov, Andrey V., Peak, David A. +42 morecore +1 more sourceUnconditional Care in Academic Emergency Departments [PDF]
, 2020 Recent news stories have explicitly stated that patients with symptoms of COVID-19 were "turned away" from emergency departments. This commentary addresses these serious allegations, with an attempt to provide the perspective of academic emergency ...Burton, John H, Miner, James R, Ian B.K. Martin, Lall, Michelle D, Newgard, Craig D., Coates, Wendy C, Angela M. Mills, Bird, Steven B., Mills, Angela M, Newgard, Craig D, John H. Burton, Dorner, Stephen C., Kaji, Amy H., Holmes, James F, Michelle D. Lall, Holmes, James F., Kaji, Amy H, Martin, Ian BK, Burton, John H., Kline, Jeffrey A, Megan L. Ranney, Dorner, Stephen C, Richard E. Wolfe, Steven B. Bird, Quest, Tammie, Stephen C. Dorner, Amy H. Kaji, Mills, Angela M., Ranney, Megan L, Zachary F. Meisel, Craig D. Newgard, Meisel, Zachary F, Coates, Wendy C., Wolfe, Richard E, Wendy C. Coates, Meisel, Zachary F., Christopher R. Carpenter, Miner, James R., Jeffrey A. Kline, James R. Miner, Martin, Ian B. K., Lall, Michelle D., Bird, Steven B, Carpenter, Christopher R., James F. Holmes, Kline, Jeffrey A., Ranney, Megan L., Carpenter, Christopher R, Tammie Quest, Wolfe, Richard E. +49 morecore +1 more source
