Results 61 to 70 of about 4,262,214 (412)

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Can emergency medicine research benefit from adaptive design clinical trials? [PDF]

, 2017
Background: Adaptive design clinical trials use preplanned interim analyses to determine whether studies should be stopped or modified before recruitment is complete. Emergency medicine trials are well suited to these designs as many have a short time to
Flight, L., Goodacre, S., Julious, S.A.
core   +1 more source

Experiences of underrepresented faculty in pediatric emergency medicine

Academic Emergency Medicine, 2020
The aim of this study is to elucidate the unique challenges faced by pediatric emergency medicine (PEM) physicians from racial/ethnic groups underrepresented in medicine (URiM).
Bianca Nfonoyim, Ashley Martin, Angela M. Ellison, J. Wright, Tiffani J. Johnson   +4 more
semanticscholar   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Obstacles and Challenges to Implementing Multi-departmental QI at a Large, Academic Training Center-Lessons Learned from a HCV Screening Program [PDF]

, 2017
Objectives: We aimed to double the HCV screening rate of ‘baby-boomers’ admitted to the medicine teaching service at Methodist Hospital over the course of 6 months and demonstrate improved linkage to care for HCV RNA+ individuals. Initial efforts were a
Arastu, MD, S., Fenkel, MD, Jonathan M, Javia, MD, Amy, Kasprowicz, MD, MPH, Eric M., Mammen, MD, MPH, Priya, Yalamanchili, MD, Silpa, Zale, MPH, Madalene   +6 more
core   +1 more source

Research priorities for data collection and management within global acute and emergency care systems. [PDF]

, 2013
Barriers to global emergency care development include a critical lack of data in several areas, including limited documentation of the acute disease burden, lack of agreement on essential components of acute care systems, and a lack of consensus on key ...
Bisanzo, Mark, Dworkis, Daniel, Hansoti, Bhakti, Hauswald, Mark, Mowafi, Hani, Obermeyer, Ziad, Reynolds, Teri A, Seidenberg, Phil   +7 more
core   +2 more sources

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Hyperbaric medicine in emergencies

Vojnosanitetski pregled, 2008
<zakljucak> Imajuci u vidu mali broj kontraindikacija, primena HBOT od velike je koristi u zbrinjavanju urgentnih stanja, narocito u kombinaciji sa hirurskim i medikamentnim procedurama. .
Uros Zoranovic, Dusan Micevic, Milorad Rabrenovic, Radomir Matunovic, Veljko Todorovic, Violeta Rabrenovic   +5 more
openaire   +4 more sources

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Emergency Medicine Dermatology [PDF]

Journal of Education and Teaching in Emergency Medicine, 2017
Audience: This modified team-based learning (mTBL) exercise is appropriate for junior and senior emergency medicine learners. Introduction: Rashes and dermatologic complaints are common in the emergency department. It is essential that emergency physicians understand various types of lesions and rashes as well as be able to distinguish between benign ...
openaire   +4 more sources