Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen +8 more
wiley +1 more source
Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis
Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...
Yue‐Long Qiao +10 more
wiley +1 more source
Feasibility of a Mental Health App Intervention for Emergency Service Workers and Volunteers: Single-Arm Pilot Study. [PDF]
Meuldijk D +5 more
europepmc +1 more source
The characterization of a hospitalized population at the pediatric emergency service of Mother and Child Hospital, Marrakech, Morocco. [PDF]
Jbari S +4 more
europepmc +1 more source
A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness
Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger +17 more
wiley +1 more source
Interest of Lung Ultrasound in the Management of Acute Heart Failure in Post-Emergency Service. [PDF]
Bel Alonso E +8 more
europepmc +1 more source
COVID-19 Pandemic: Analysis of Health Effects on Emergency Service Nursing Workers via a Qualitative Approach. [PDF]
Vianna ECDC +14 more
europepmc +1 more source
Emergency Mental Health and Traumatic Stress Services Branch
US Department of Health and Human Services; Substance Abuse and Mental Health Services Administration
openalex +1 more source

