Results 21 to 30 of about 344,311 (256)

Unheard and Under‐Supported: Health‐Related Quality of Life in Children, Adolescents, and Young Adults With Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
Abstract Background Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy affecting millions of individuals worldwide. The clinical expression and psychosocial burden of SCD vary widely across geographical, cultural, and healthcare system contexts, underscoring the need for setting‐specific approaches to assessment.
Desiré Fantasia, Giulia Reggiani, Elizabeth J. Maran, Maria Elisa Delle Fave, Ilaria Baido, Anna Chiara Frigo, Maria Paola Boaro, Raffaella Colombatti   +7 more
wiley   +1 more source

Fatigue impact of mixed reality in mass casualty incidents training

BMC Digital Health
Background Fatigue is a multifaceted state characterized by a significant lack of energy or motivation; which is perceived by the individual to interfere with usual and desired activities; it can hinder an individual’s functioning.
Ana María Cintora-Sanz, Raúl Muñoz-Romo, Alberto Blanco-Lara, Paula Sanchíz-Torres, Tatiana Vazquéz-Rodríguez, Helmut Schrom-Feiertag, Carmen Cardós-Alonso   +6 more
doaj   +1 more source

CD8-Lymphocytic Phenotype Significance in Primary Multiple and Familial Melanoma with Various CDKN2A Mutational Status

Medicina, 2023
Background and Objectives: In the realm of the rising incidence of cutaneous and mucous melanoma, CDKN2A mutations characterize familial and multiple primary melanoma cases.
Luana-Andreea Boşoteanu, Emma Gheorghe, Mariana Aşchie, Georgeta Camelia Cozaru, Mariana Deacu, Gabriela Izabela Bălțătescu, Cristian Ionuț Orășanu, Mǎdǎlina Boşoteanu   +7 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Patient-reported side effects and satisfaction of pre-hospital analgesia with low-dose esketamine: a cross-sectional study

BMC Emergency Medicine, 2023
Background Analgesia is a core intervention in emergency medicine. Pain is subjective, so patient-reported experience with pain and analgesia is essential for healthcare professionals.
David Häske, Fabian Eppler, Niklas Heinemann, Benjamin Schempf   +3 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Prevalence of prehospital pain and pain assessment difference between patients and paramedics: a prospective cross-sectional observational study

Scientific Reports
Adequate analgesia is one of the most important interventions in emergency medicine. However, studies suggest that many patients are undertreated for pain. There can be many reasons why patients assess their pain differently to the paramedics. This study
David Häske, Wolfgang Dorau, Fabian Eppler, Niklas Heinemann, Florian Metzger, Benjamin Schempf   +5 more
doaj   +1 more source

Antibiotic Susceptibility of Isolates from Blood of Patients in Intensive Care Units of Emergency Medical Service

Антибиотики и Химиотерапия, 2020
The microbiological tests of 769 blood samples from 220 patients, treated in 4 intensive care units of the N.V. Sklifosovsky Research Institute for Emergency Medical Service within a period from January 2009 to June 2010, were analysed.
T. V. Chernenkaya, L. A. Borisova, T. YU. Vorobyeva, I. V. Aleksandrova, D. A. Kosolapov   +4 more
doaj  

EMERGENCY SERVICES

Indian journal of nephrology
This abstract introduces an Emergency Services System designed to streamline emergency response processes. The system accommodates patients, ambulance drivers, and hospitals, fire brigades and fire locations through a user- friendly interface. Users register and log in to access functionalities tailored to their roles: patients can book ambulances ...
null Yogita Shelar, null Akhil B Hojane, null Sakshi Patel, null Amol Hate, null Dhruv Shah   +4 more
  +6 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source