Results 21 to 30 of about 375,627 (265)

Impact of drug and equipment preparation on pre-hospital emergency Anaesthesia (PHEA) procedural time, error rate and cognitive load

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2018
Background We examined the effect of advanced preparation and organisation of equipment and drugs for Pre-hospital Emergency Anaesthesia (PHEA) and tracheal intubation on procedural time, error rates, and cognitive load.
Paul Swinton, Alasdair R. Corfield, Chris Moultrie, David Percival, Jeffrey Proctor, Neil Sinclair, Zane B. Perkins   +6 more
doaj   +1 more source

Uncovering Inequities: The Role of Social Determinants of Health in Hospitalized Adolescents and Young Adults With Heavy Menstrual Bleeding

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Heavy menstrual bleeding (HMB) is a common condition among adolescents and young adults (AYAs) and is the leading cause of iron deficiency anemia (IDA) in this population. Growing evidence suggests that social determinants of health (SDOH) influence menstrual bleeding patterns, access to care, and treatment. However, no studies have
Maria Carter‐Febres, Cristina Tarango, Ashley Childress, Chunyan Liu, Evan Thomas, Jennifer Pomales, Eric S. Mullins   +6 more
wiley   +1 more source

Fatigue impact of mixed reality in mass casualty incidents training

BMC Digital Health
Background Fatigue is a multifaceted state characterized by a significant lack of energy or motivation; which is perceived by the individual to interfere with usual and desired activities; it can hinder an individual’s functioning.
Ana María Cintora-Sanz, Raúl Muñoz-Romo, Alberto Blanco-Lara, Paula Sanchíz-Torres, Tatiana Vazquéz-Rodríguez, Helmut Schrom-Feiertag, Carmen Cardós-Alonso   +6 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Early resuscitation priorities in two-provider EMS crews: an interpretive commentary

BMC Emergency Medicine
Background International resuscitation guidelines are grounded in physiological principles and outcome-based evidence, but they implicitly assume staffing levels that allow multiple time-critical interventions to be delivered in parallel.
Roman Sýkora, Jiří Chvojka, Nikola Kukačková, Viktorie Šimečková, Jiří Smetana   +4 more
doaj   +1 more source

Out-of-hospital resuscitation of a 3 month old boy presenting with recurrent ventricular fibrillation cardiac arrest: a case report

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2021
A 3 month old boy, with no known health conditions, suffered a sudden collapse at home. On first EMS arrival, ventricular fibrillation (VF) cardiac arrest was identified and resuscitation following UK national guidelines was initiated.
Peter Kingsley, Jonathan Merefield, Robert G. Walker, Fred W. Chapman, Mark Faulkner   +4 more
doaj   +1 more source

CD8-Lymphocytic Phenotype Significance in Primary Multiple and Familial Melanoma with Various CDKN2A Mutational Status

Medicina, 2023
Background and Objectives: In the realm of the rising incidence of cutaneous and mucous melanoma, CDKN2A mutations characterize familial and multiple primary melanoma cases.
Luana-Andreea Boşoteanu, Emma Gheorghe, Mariana Aşchie, Georgeta Camelia Cozaru, Mariana Deacu, Gabriela Izabela Bălțătescu, Cristian Ionuț Orășanu, Mǎdǎlina Boşoteanu   +7 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Patient-reported side effects and satisfaction of pre-hospital analgesia with low-dose esketamine: a cross-sectional study

BMC Emergency Medicine, 2023
Background Analgesia is a core intervention in emergency medicine. Pain is subjective, so patient-reported experience with pain and analgesia is essential for healthcare professionals.
David Häske, Fabian Eppler, Niklas Heinemann, Benjamin Schempf   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source