Results 71 to 80 of about 6,940,298 (313)

Pulmonary paracoccidioidomycosis associated with septic shock in an immunocompetent patient. Case report

Case Reports, 2017
Introduction. Paracoccidioidomycosis (PCM) is a chronic granulomatous disease caused by the dimorphic fungus known as Paracoccidioides brasiliensis.
Freddy Mauricio Quintero Alvarez, José Mauricio Garcia-Habeych, Juan Pablo Baez Duarte, Jessica Paola Montes Ortiz, Sergio Andres Mendinueta Giacometto   +4 more
doaj   +1 more source

Trends and barriers of emergency medical service use in Addis Ababa; Ethiopia

BMC Emergency Medicine, 2019
BackgroundThe increasing burdens of trauma and time sensitive non-communicable disease in Addis Ababa necessitate a robust emergency medical care system.
Menbeu Sultan, Yonas Abebe, Assefu Welde Tsadik, Asmamaw Ababa, Alegnta Gebre Yesus, N. Mould-Millman   +5 more
semanticscholar   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Use of Self-Efficacy Scale in Mass Casualty Incidents During Drill Exercises

BMC Health Services Research
Introduction Medical First Responders (MFRs) in the emergency department SUMMA 112 are tasked with handling the initial management of Mass Casualty Incidents (MCI) and building response capabilities.
María Carmen Cardós-Alonso, Miguel Inzunza, Lina Gyllencreutz, Salvador Espinosa, Tatiana Vázquez, Maria Aranzazu Fernandez, Alberto Blanco, Ana María Cintora-Sanz   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The CoolCot trial: active methods of therapeutic hypothermia for newborns with hypoxic ischaemic encephalopathy (HIE) during neonatal transport: a study protocol for a randomised controlled trial comparing battery-enabled servo-controlled cooling blankets and ice-gel pack methods

Trials
Background Impaired oxygen delivery or blood flow to the brain around the time of birth can cause injury. Hypoxic ischaemic encephalopathy (HIE) is a leading cause of death and disability in term and near-term infants.
Adam Heathcote, Kate Hooper, Matt Cooper, Sebastian Lee, Fan Tang, Vamsi Batta, Saumil Desai, Jacqueline Gardiner, Alex Wilson, Kylie McDonald, Alysha Timoney, Tess Watson, Jonathan Davis   +12 more
doaj   +1 more source

Outcome, quality of life and direct costs after out-of-hospital cardiac arrest in an urban region of Switzerland

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2019
Background Considering the significant morbidity and mortality of out-of-hospital cardiac arrest, only little data on survival or quality of life after successful resuscitation is available in Europe.
Raphael Ruch, Laura Stoessel, Philipp Stein, Michael Thomas Ganter, Daniel Anthony Button   +4 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

The impact of additional special emergency medical service units on non-traumatic adult out-of-hospital cardiac arrest outcomes in a high-resource metropolitan area

Resuscitation Plus
Background: Out-of-hospital cardiac arrest (OHCA) requires an effective cardiopulmonary resuscitation (CPR) and emergency medical service (EMS) response, yet survival rates remain low at 8.0–11.3 %.
Andrea Kornfehl, Mario Krammel, Daniel Grassmann, Maximilian de Zordo, Roman Brock, Christoph Veigl, Rene Adler, Sabine Dunkl, Mathias Gatterbauer, Philipp Gonzo, Bertram Schadler, Patrick Aigner, Michael Girsa, Patrick Glaninger, Andreas Zajicek, Patrick Sulzgruber, Thomas Uray, Sebastian Schnaubelt   +17 more
doaj   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source