Results 71 to 80 of about 12,409,837 (292)
FEBS Letters, EarlyView.The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva +1 more
wiley +1 more source
Reduction and Emergence in Bose-Einstein Condensates [PDF]
, 2009 A closer look at some proposed Gedanken-experiments on BECs promises to shed light on several aspects of reduction and emergence in physics. These include the relations between classical descriptions and different quantum treatments of macroscopic systems, and the emergence of new properties and even new objects as a result of spontaneous symmetry ...
arxiv +1 more source
Average Response Curves for Treatment Time in the Emergency Department [PDF]
arXiv, 2022 We estimate average responses curves for treatment time in the Emergency Department (ED). Extending treatment time is considered a promising solution for improving admission decisions. Providing empirical support for this solution, however, is difficult because this intervention (treatment) is a continuous time-to-event; is strongly influenced by ...
arxiv
Molecular Oncology, EarlyView.Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker +14 more
wiley +1 more source
Timing of Pathogen Adaptation to a Multicomponent Treatment [PDF]
, 2013 The sustainable use of multicomponent treatments such as combination therapies, combination vaccines/chemicals, and plants carrying multigenic resistance requires an understanding of how their population-wide deployment affects the speed of the pathogen adaptation.
arxiv +1 more source
Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients
Molecular Oncology, EarlyView.Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha +6 more
wiley +1 more source
Comparison of meta-learners for estimating multi-valued treatment heterogeneous effects [PDF]
arXiv, 2022 Conditional Average Treatment Effects (CATE) estimation is one of the main challenges in causal inference with observational data. In addition to Machine Learning based-models, nonparametric estimators called meta-learners have been developed to estimate the CATE with the main advantage of not restraining the estimation to a specific supervised ...
arxiv
Molecular Oncology, EarlyView.This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke +12 more
wiley +1 more source
Understanding disease control: influence of epidemiological and economic factors [PDF]
, 2011 We present a local spread model of disease transmission on a regular network and compare different control options ranging from treating the whole population to local control in a well-defined neighborhood of an infectious individual. Comparison is based on a total cost of epidemic, including cost of palliative treatment of ill individuals and ...
arxiv +1 more source
Adaptive A/B Tests and Simultaneous Treatment Parameter Optimization [PDF]
arXiv, 2022 Constructing asymptotically valid confidence intervals through a valid central limit theorem is crucial for A/B tests, where a classical goal is to statistically assert whether a treatment plan is significantly better than a control plan. In some emerging applications for online platforms, the treatment plan is not a single plan, but instead ...
arxiv