Results 81 to 90 of about 12,409,837 (292)

A qualitative study of emergency department patients who survived an opioid overdose: Perspectives on treatment and unmet needs

Academic Emergency Medicine, 2020
Emergency medicine clinicians are uniquely positioned to deliver interventions to enhance linkage to evidence‐based treatment for opioid use disorder (OUD) in the acute overdose period, yet little is known about patient perspectives to effectively engage
K. Hawk, L. Grau, D. Fiellin, M. Chawarski, P. O'Connor, N. Cirillo, Chris Breen, G. D'Onofrio   +7 more
semanticscholar   +1 more source

Drug-induced QT interval prolongation in cancer patients

Oncology Reviews, 2011
Cancer patients are at an increased risk for QT interval prolongation and subsequent potentially fatal Torsade de pointes tachycardia due to the multiple drugs used for treatment of malignancies and the associated symptoms and complications.
Torben K. Becker, Sai-Ching J. Yeung
doaj   +1 more source

Integrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to ALK inhibitors in lung cancer

Molecular Oncology, EarlyView.
We propose an efficient strategy to suppress ALK inhibitor (ALKi) resistance. By analyzing transcriptome data, we identified emetine as a potential inhibitor. We demonstrated that emetine exhibited effectiveness in inhibiting the growth of ALKi‐resistant cells, and further interpreted its impact on the resistant signatures through drug‐induced RNA ...
Sang‐Min Park, Keeok Haam, Haejeong Heo, Doyeong Kim, Min‐Ju Kim, Hyo‐Jung Jung, Seongwon Cha, Mirang Kim, Haeseung Lee   +8 more
wiley   +1 more source

Causal Effect Estimation: Recent Advances, Challenges, and Opportunities [PDF]

arXiv, 2023
Causal inference has numerous real-world applications in many domains, such as health care, marketing, political science, and online advertising. Treatment effect estimation, a fundamental problem in causal inference, has been extensively studied in statistics for decades.
arxiv  

Accidental Chronic Poisoning with Methotrexate; Report of Two Cases

Archives of Academic Emergency Medicine, 2016
Methotrexate has been used widely in dermatology, oncology and rheumatology fields. However, methotrexate-induced mucocutaneous lesions may occur in rare cases.
Reza Bidaki, Mojgan Kian, Hamid Owliaey, Mojtaba Babaei Zarch, Masoud Feysal   +4 more
doaj   +1 more source

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

Molecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou, Aliki Ntzifa, Victoria Tserpeli, Ioanna Balgkouranidou, Alkistis Papatheodoridi, Evangelia Razis, Helena Linardou, Christos Papadimitriou, Amanda Psyrri, Flora Zagouri, Stylianos Kakolyris, Evi Lianidou   +11 more
wiley   +1 more source

Qini Curves for Multi-Armed Treatment Rules [PDF]

arXiv, 2023
Qini curves have emerged as an attractive and popular approach for evaluating the benefit of data-driven targeting rules for treatment allocation. We propose a generalization of the Qini curve to multiple costly treatment arms, that quantifies the value of optimally selecting among both units and treatment arms at different budget levels. We develop an
arxiv  

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Research: Educational and Psychological Issues Substantial reductions in the number of diabetic ketoacidosis and severe hypoglycaemia episodes requiring emergency treatment lead to reduced costs after structured education in adults with Type 1 diabetes

Diabetic Medicine, 2014
To determine the impact of structured education promoting flexible intensive insulin therapy on rates of diabetic ketoacidosis, and the costs associated with emergency treatment for severe hypoglycaemia and ketoacidosis in adults with Type 1 diabetes.
J. Elliott, Richard Jacques, J. Kruger, Michael J. Campbell, Stephanie A Amiel, Peter Mansell, Jane Speight, Alan Brennan, Simon Heller   +8 more
semanticscholar   +1 more source

Chemically Activated Cooling Vest’s Effect on Cooling Rate Following Exercise-Induced Hyperthermia: A Randomized Counter-Balanced Crossover Study

Medicina, 2020
Background and objectives: Exertional heat stroke (EHS) is a potentially lethal, hyperthermic condition that warrants immediate cooling to optimize the patient outcome.
Yuri Hosokawa, Luke N. Belval, William M. Adams, Lesley W. Vandermark, Douglas J. Casa   +4 more
doaj   +1 more source