Results 151 to 160 of about 407,798 (310)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Emergent grammar from a minimal cognitive architecture [Elektronisk resurs]

In this paper, we introduce a minimal cognitive architecture designed to explore the mechanism sunderlying human language learning abilities. Our model inspired by research in artificial intelligence incorporates sequence memory, chunking and ...
Jon-And, Anna,, Michaud, Jérôme,
core  

Early Outcome of Elective and Emergent Endovascular Aortic Repair with the Minos^TM Abdominal Aortic Stent-Graft. [PDF]

J Clin Med
Krüger JC, Menges AL, Pöll V, Reutersberg B, Zimmermann A.   +4 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Tandem occlusions after emergent stenting in acute ischemic stroke: A retrospective cohort study from a comprehensive stroke center's experience (TOESIS study). [PDF]

J Int Med Res
Le TM, Tran CC, Nguyen GL, Nguyen NH, Nguyen TT, Tran LBM.   +5 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Analyzing domestic violence with topographic maps: a comparative study. [PDF]

Topographic maps are an appealing exploratory instrument for discovering new knowledge from databases. During the recent years, several variations on the Self Organizing Maps (SOM) were introduced in the literature.
Elzinga, Paul, Dedene, Guido, Van Hulle, Marc, Poelmans, Jonas, Viaene, Stijn   +4 more
core  

Checklist of bees (Hymenoptera: Apoidea) from managed emergent wetlands in the lower Mississippi Alluvial Valley of Arkansas

Biodiversity Data Journal, 2018
Phillip Stephenson, Terry Griswold, Michael Arduser, Ashley Dowling, David Krementz   +4 more
doaj   +3 more sources

Arcobacter: un patógeno emergente de origen alimentario

Archivos Latinoamericanos de Nutrición
En las últimas tres décadas, se han identificado gran número de enfermedades emergentes que afectan al ser humano, la mayoría de las cuales son de origen infeccioso e incluyen enfermedades bacterianas, virales, parasitarias, entre otras.
Gerardo Calvo, María Laura Arias, Heriberto Fernández   +2 more
doaj