Results 201 to 210 of about 822,085 (315)

Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation. [PDF]

Pharmaceutics, 2021
Schijns V, Majhen D, van der Ley P, Thakur A, Summerfield A, Berisio R, Nativi C, Fernández-Tejada A, Alvarez-Dominguez C, Gizurarson S, Zamyatina A, Molinaro A, Rosano C, Jakopin Ž, Gursel I, McClean S.   +15 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

CDC's Division of Vector\uc2\uadBorne Diseases

Virtually everyone on earth is vulnerable to diseases from viruses and bacteria transmitted to people through bites of mosquitoes, ticks, fleas, and other insects, known as vectors. West Nile virus, Lyme disease, and Rocky Mountain spotted fever are some

core  

Editorial: RNA vaccines for prevalent and newly emerging diseases. [PDF]

Front Immunol
López-Camacho C, Alameh MG, Peer D, Culis P.   +3 more
europepmc   +1 more source

Contributions of the international plant science community to the fight against infectious diseases in humans-part 2: Affordable drugs in edible plants for endemic and re-emerging diseases. [PDF]

Plant Biotechnol J, 2021
He W, Baysal C, Lobato Gómez M, Huang X, Alvarez D, Zhu C, Armario-Najera V, Blanco Perera A, Cerda Bennaser P, Saba-Mayoral A, Sobrino-Mengual G, Vargheese A, Abranches R, Alexandra Abreu I, Balamurugan S, Bock R, Buyel JF, da Cunha NB, Daniell H, Faller R, Folgado A, Gowtham I, Häkkinen ST, Kumar S, Sathish Kumar R, Lacorte C, Lomonossoff GP, Luís IM, K-C Ma J, McDonald KA, Murad A, Nandi S, O'Keef B, Parthiban S, Paul MJ, Ponndorf D, Rech E, Rodrigues JCM, Ruf S, Schillberg S, Schwestka J, Shah PS, Singh R, Stoger E, Twyman RM, Varghese IP, Vianna GR, Webster G, Wilbers RHP, Christou P, Oksman-Caldentey KM, Capell T.   +51 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Editorial: Wildlife parasitology: emerging diseases and neglected parasites. [PDF]

Front Vet Sci
Deak G, Germitsch N, Rojas A, Sazmand A.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Emerging Diseases in Spain Strawberry Crops: Neopestalotiopsis Leaf and Crown Rot and Fusarium Wilt. [PDF]

Plants (Basel)
Avilés M, Pastrana AM, Borrero C.
europepmc   +1 more source

Units for vigilance of emerging diseases based on wastewater treatment plants (WWTP-UVED). [PDF]

Microb Biotechnol, 2020
Barros-Rodríguez A, Manzanera M.
europepmc   +1 more source