Results 21 to 30 of about 822,085 (315)

SARS-CoV-2 genomic and subgenomic RNAs in diagnostic samples are not an indicator of active replication

Nature Communications, 2020
During SARS-CoV-2 replication subgenomic RNAs (sgRNA) are transcribed and subsequently translated into viral proteins. Here, Alexandersen et al. provide evidence that sgRNA is not necessarily an indicator for active viral replication, but can be detected
Soren Alexandersen, Anthony Chamings, Tarka Raj Bhatta   +2 more
doaj   +1 more source

Immune gene expression analysis indicates the potential of a self-amplifying Covid-19 mRNA vaccine

npj Vaccines, 2022
Remarkable potency has been demonstrated for mRNA vaccines in reducing the global burden of the ongoing COVID-19 pandemic. An alternative form of the mRNA vaccine is the self-amplifying mRNA (sa-mRNA) vaccine, which encodes an alphavirus replicase that ...
Eugenia Z. Ong, Jia Xin Yee, Justin S. G. Ooi, Ayesa Syenina, Ruklanthi de Alwis, Shiwei Chen, Jean X. Y. Sim, Shirin Kalimuddin, Yan Shan Leong, Yvonne F. Z. Chan, Rose Sekulovich, Brian M. Sullivan, Kelly Lindert, Sean B. Sullivan, Pad Chivukula, Steven G. Hughes, Jenny G. Low, Eng Eong Ooi, Kuan Rong Chan   +18 more
doaj   +1 more source

The emergence of Lyme disease [PDF]

Journal of Clinical Investigation, 2004
Since its identification nearly 30 years ago, Lyme disease has continued to spread, and there have been increasing numbers of cases in the northeastern and north central US. The Lyme disease agent, Borrelia burgdorferi, causes infection by migration through tissues, adhesion to host cells, and evasion of immune clearance.
Allen C, Steere, Jenifer, Coburn, Lisa, Glickstein   +2 more
openaire   +2 more sources

Understanding the failure of a behavior change intervention to reduce risk behaviors for avian influenza transmission among backyard poultry raisers in rural Bangladesh: a focused ethnography

BMC Public Health, 2016
Background The spread of the highly pathogenic avian influenza (HPAI) H5N1 virus among poultry and humans has raised global concerns and has motivated government and public health organizations to initiate interventions to prevent the transmission of ...
Nadia Ali Rimi, Rebeca Sultana, Kazi Ishtiak-Ahmed, Md Zahidur Rahman, Marufa Hasin, M. Saiful Islam, Eduardo Azziz-Baumgartner, Nazmun Nahar, Emily S. Gurley, Stephen P. Luby   +9 more
doaj   +1 more source

Spike-Independent Infection of Human Coronavirus 229E in Bat Cells

Microbiology Spectrum, 2023
Bats are the reservoir for numerous human pathogens, including coronaviruses. Despite many coronaviruses having descended from bat ancestors, little is known about virus-host interactions and broader evolutionary history involving bats.
Marcus G. Mah, Martin Linster, Dolyce H. W. Low, Yan Zhuang, Jayanthi Jayakumar, Firdaus Samsudin, Foong Ying Wong, Peter J. Bond, Ian H. Mendenhall, Yvonne C. F. Su, Gavin J. D. Smith   +10 more
doaj   +1 more source

Twenty-two years of dengue outbreaks in Bangladesh: epidemiology, clinical spectrum, serotypes, and future disease risks

Tropical Medicine and Health, 2023
Dengue is the most rapidly spreading mosquito-borne disease and has become a major public health threat, particularly for tropical and subtropical countries including Bangladesh. This comprehensive review aims to summarize the overall scenario of dengue,
Mohammad Sorowar Hossain, Abdullah Al Noman, SM Abdullah Al Mamun, Abdullah Al Mosabbir   +3 more
doaj   +1 more source

Emerging infectious diseases

Communicable Diseases Intelligence, 1997
Over the last two decades, there has been the emergence of previously unknown infectious diseases and the re-emergence of diseases thought to be in decline. This is the result of social, economic, political and ecological factors, and the interactions of organisms, hosts and the environment.
openaire   +2 more sources

Reduced dengue virus pre-membrane protein-HMGB1 interaction activates host cell transcription to attenuate infection

npj Vaccines
To successfully complete an infection lifecycle, viruses have to avoid activating host antiviral and transcriptional responses to avoid disrupting cellular processes and cause premature host cell death.
Tanamas Siriphanitchakorn, Justin S. G. Ooi, Wy Ching Ng, Hwee Cheng Tan, Summer L. Zhang, Dorothy H. L. Ng, Xin Yap, Jia Xin Yee, Qiao Zheng, Yi Ting Tan, Eugenia Z. Ong, Kuan Rong Chan, Milly M. Choy, Eng Eong Ooi   +13 more
doaj   +1 more source

Attenuated dengue viruses are genetically more diverse than their respective wild-type parents

npj Vaccines, 2021
Dengue poses a significant burden of individual health, health systems and the economy in dengue endemic regions. As such, dengue vaccine development has been an active area of research.
Amanda Makha Bifani, Milly M. Choy, Hwee Cheng Tan, Eng Eong Ooi   +3 more
doaj   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source