Results 21 to 30 of about 4,319,558 (311)

SARS-CoV-2 genomic and subgenomic RNAs in diagnostic samples are not an indicator of active replication

Nature Communications, 2020
During SARS-CoV-2 replication subgenomic RNAs (sgRNA) are transcribed and subsequently translated into viral proteins. Here, Alexandersen et al. provide evidence that sgRNA is not necessarily an indicator for active viral replication, but can be detected
Soren Alexandersen, Anthony Chamings, Tarka Raj Bhatta   +2 more
doaj   +1 more source

Emerging infectious diseases [PDF]

Journal of Clinical Investigation, 2004
Human population growth, technological advances, and changing social behaviors lead to the selection of new microbial pathogens. Antimicrobial drugs, vaccines, diagnostics, and treatments for emerging infectious diseases must be developed. The selective forces that drive the emergence of new infectious diseases, and the implications for our survival ...
openaire   +2 more sources

Immune gene expression analysis indicates the potential of a self-amplifying Covid-19 mRNA vaccine

npj Vaccines, 2022
Remarkable potency has been demonstrated for mRNA vaccines in reducing the global burden of the ongoing COVID-19 pandemic. An alternative form of the mRNA vaccine is the self-amplifying mRNA (sa-mRNA) vaccine, which encodes an alphavirus replicase that ...
Eugenia Z. Ong, Jia Xin Yee, Justin S. G. Ooi, Ayesa Syenina, Ruklanthi de Alwis, Shiwei Chen, Jean X. Y. Sim, Shirin Kalimuddin, Yan Shan Leong, Yvonne F. Z. Chan, Rose Sekulovich, Brian M. Sullivan, Kelly Lindert, Sean B. Sullivan, Pad Chivukula, Steven G. Hughes, Jenny G. Low, Eng Eong Ooi, Kuan Rong Chan   +18 more
doaj   +1 more source

Spike-Independent Infection of Human Coronavirus 229E in Bat Cells

Microbiology Spectrum, 2023
Bats are the reservoir for numerous human pathogens, including coronaviruses. Despite many coronaviruses having descended from bat ancestors, little is known about virus-host interactions and broader evolutionary history involving bats.
Marcus G. Mah, Martin Linster, Dolyce H. W. Low, Yan Zhuang, Jayanthi Jayakumar, Firdaus Samsudin, Foong Ying Wong, Peter J. Bond, Ian H. Mendenhall, Yvonne C. F. Su, Gavin J. D. Smith   +10 more
doaj   +1 more source

Emerging infectious diseases [PDF]

Medicine, 2014
Resumen El espectro de patógenos humanos y las enfermedades infecciosas que causan está cambiando continuamente a través de la evolución y los cambios en la forma en que las poblaciones humanas interactúan con su entorno y entre sí. Los nuevos patógenos humanos surgen con mayor frecuencia de un reservorio animal, lo que enfatiza el papel central que ...
openaire   +6 more sources

Understanding the failure of a behavior change intervention to reduce risk behaviors for avian influenza transmission among backyard poultry raisers in rural Bangladesh: a focused ethnography

BMC Public Health, 2016
Background The spread of the highly pathogenic avian influenza (HPAI) H5N1 virus among poultry and humans has raised global concerns and has motivated government and public health organizations to initiate interventions to prevent the transmission of ...
Nadia Ali Rimi, Rebeca Sultana, Kazi Ishtiak-Ahmed, Md Zahidur Rahman, Marufa Hasin, M. Saiful Islam, Eduardo Azziz-Baumgartner, Nazmun Nahar, Emily S. Gurley, Stephen P. Luby   +9 more
doaj   +1 more source

Attenuated dengue viruses are genetically more diverse than their respective wild-type parents

npj Vaccines, 2021
Dengue poses a significant burden of individual health, health systems and the economy in dengue endemic regions. As such, dengue vaccine development has been an active area of research.
Amanda Makha Bifani, Milly M. Choy, Hwee Cheng Tan, Eng Eong Ooi   +3 more
doaj   +1 more source

Reduced dengue virus pre-membrane protein-HMGB1 interaction activates host cell transcription to attenuate infection

npj Vaccines
To successfully complete an infection lifecycle, viruses have to avoid activating host antiviral and transcriptional responses to avoid disrupting cellular processes and cause premature host cell death.
Tanamas Siriphanitchakorn, Justin S. G. Ooi, Wy Ching Ng, Hwee Cheng Tan, Summer L. Zhang, Dorothy H. L. Ng, Xin Yap, Jia Xin Yee, Qiao Zheng, Yi Ting Tan, Eugenia Z. Ong, Kuan Rong Chan, Milly M. Choy, Eng Eong Ooi   +13 more
doaj   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Hali ya dawa kukataa kufanya kazi

, 2020
Learn about how you can play your part in preventing antimicrobial resistance. This Swahili version of the video was created primarily for and East African audience, and was funded by a UK BBSRC/GCRF Public Engagement grant (https://bbsrc.ukri.org ...
Zoonotic and Emerging Diseases Research Team
core   +1 more source