Results 71 to 80 of about 4,319,558 (311)

Emerging and zoonotic infectious diseases [PDF]

The National Center for Emerging and Zoonotic Infectious Diseases is committed to protecting people from domestic and global health threats, including: Foodborne illness; Infections that spread in hospitals; Infections that are resistant to antibiotics ...

core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Bringing together emerging and endemic zoonoses surveillance: shared challenges and a common solution [PDF]

, 2012
Early detection of disease outbreaks in human and animal populations is crucial to the effective surveillance of emerging infectious diseases. However, there are marked geographical disparities in capacity for early detection of outbreaks, which limit ...
Knobel, Darryn, Halliday, Jo E.B., Lembo, Tiziana, Halliday, Jo, Handel, Ian Graham, Bronsvoort, Barend M. deC., Bronsvoort, Barend M Dec, Halliday, Joanna, Auty, Harriet, Bronsvoort, Mark, Hampson, Katie, Handel, Ian, Bronsvoort, Barend Mark de Clare, Cleaveland, Sarah, Daborn, Chris, Knobel, Darryn Leslie, Mtema, Zacharia   +16 more
core   +1 more source

National Center for Emerging and Zoonotic Infectious Diseases [PDF]

The National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) aims to detect, prevent, and control infectious diseases from spreading, whether they are naturally occurring, unintentional, or the result of terrorism. The center focuses on new,

core   +2 more sources

National Prevalence and Risk Factors of Hepatitis B Virus Infection in Tunisia Two Decades After Vaccine Introduction

Vaccines
Background/Objectives: Tunisia lacks recent national data on hepatitis B virus (HBV) prevalence, particularly following the introduction of universal HBV vaccination in 1995. A national HBV seroprevalence study is essential to guide prevention strategies.
Ahlem Fourati, Meriem Ben Hadj, Sonia Dhaouadi, Aicha Hechaichi, Hejer Letaief, Mouna Safer, Amal Cherif, Farah Saffar, Souhir Chelly, Hind Bouguerra, Asma Bahrini, Khouloud Talmoudi, Takoua Chouki, Olfa Hazgui, Naila Hannachi, Olfa Bahri, Nissaf Bouafif é p Ben Alaya   +16 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Potential Role of ACE Polymorphisms in Severe Malaria: A Case Report

Case Reports in Infectious Diseases
This case aims to contribute to the debate about the role of ACE polymorphisms in malaria severity. Comprehensive studies are warranted to explore the genetic landscape in malaria-endemic regions and its implications for personalized treatment strategies.
Raffaella Pisapia, Andrea Pomicino, Giuseppina Minei, Isabella Iadevito, Alessandro Perrella   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Health-related quality of life in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post COVID-19 Condition: a systematic review

Journal of Translational Medicine
Purpose Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Post COVID-19 Condition (PCC) are debilitating, chronic multi-systemic illnesses that require multidisciplinary care.
Breanna Weigel, Maira Inderyas, Natalie Eaton-Fitch, Kiran Thapaliya, Sonya Marshall-Gradisnik   +4 more
doaj   +1 more source