Results 71 to 80 of about 9,693,931 (354)

Respiratory syncytial virus glycoprotein G impedes CX3CR1-activation by CX3CL1 and monocyte function

npj Viruses
The soluble form of the Respiratory Syncytial Virus (RSV) G protein (sG) bears resemblance to the chemokine fractalkine (CX₃CL1). Both RSV sG and CX3CL1 possess a mucin-like domain and a CX3C motif, exist in membrane-associated and soluble forms, and ...
Robert Meineke, Ayse Agac, Marie-Christin Knittler, Martin Ludlow, Albert D. M. E. Osterhaus, Guus F. Rimmelzwaan   +5 more
doaj   +1 more source

Respiratory syncytial virus-induced ADAM17 activity controls maintenance of epithelial barrier integrity and promotes syncytium formation

Journal of Virology
Respiratory syncytial virus (RSV) infection causes epithelial injury, barrier disruption, and formation of syncytia in human lung tissue; however, the regulatory host defense mechanisms involved remain poorly defined. ADAM17 is a multifunctional sheddase
Robert Meineke, Marie-Christin Knittler, Rajarshee Tagore, Nele Engling, Martin Ludlow, Albert D. M. E. Osterhaus, Guus F. Rimmelzwaan   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

COVID-19 and emerging viral infections: The case for interferon lambda

Journal of Experimental Medicine, 2020
The Viewpoint discusses the benefits and potential limitations of using interferon lambda (IFN-λ, a type III interferon) to prevent, limit, and treat COVID-19.
L. Prokunina-Olsson, Noémie Alphonse, Ruth E Dickenson, J. Durbin, J. Glenn, R. Hartmann, S. Kotenko, Helen M. Lazear, T. O'Brien, Charlotte Odendall, O. Onabajo, H. Piontkivska, D. Santer, N. Reich, A. Wack, I. Zanoni   +15 more
semanticscholar   +1 more source

Emerging viral infections

Current Opinion in Neurology, 2013
This review highlights research and development in the field of emerging viral causes of encephalitis over the past year.There is new evidence for the presence of henipaviruses in African bats. There have also been promising advances in vaccine and neutralizing antibody research against Hendra and Nipah viruses. West Nile virus continues to cause large
openaire   +4 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Cell culture medium influences RSV G protein glycosylation and recognition by monoclonal antibodies

Virology Journal
Respiratory syncytial virus (RSV) glycoprotein G is heavily glycosylated and of variable size following virus growth in transformed cell lines or primary cells. However, it is unknown if the cell culture medium can influence the patterns of glycosylation.
Nele Engling, Marie-Christin Knittler, Rajarshee Tagore, Martin Ludlow, Albert D.M.E. Osterhaus, Guus F. Rimmelzwaan, Robert Meineke   +6 more
doaj   +1 more source

Differential innate immune activation by wild-type and NSs-deficient RVFV strains in human blood monocytes

Emerging Microbes and Infections
Rift Valley fever virus (RVFV) is a Phlebovirus causing febrile and haemorrhagic illness in ruminants and humans. The viral protein NSs is a major virulence factor that suppresses the IFN-β response in various hosts.
Niranjana Nair, Julia Friese, Paul J. Wichgers Schreur, Albert D. M. E. Osterhaus, Guus F. Rimmelzwaan, Chittappen Kandiyil Prajeeth   +5 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Quantifying Neutralizing Antibodies in Patients with COVID-19 by a Two-Variable Generalized Additive Model

mSphere, 2022
Considering the urgent demand for faster methods to quantify neutralizing antibody titers in patients with coronavirus (CoV) disease 2019 (COVID-19), developing an analytical model or method to replace the conventional virus neutralization test (NT) is ...
Kuan-Ting Liu, Yu-Nong Gong, Chung-Guei Huang, Peng-Nien Huang, Kar-Yee Yu, Hou-Chen Lee, Sun-Che Lee, Huan-Jung Chiang, Yu-An Kung, Yueh-Te Lin, Mei-Jen Hsiao, Po-Wei Huang, Sheng-Yu Huang, Hsin-Tai Wu, Chih-Ching Wu, Rei-Lin Kuo, Kuan-Fu Chen, Chuan-Tien Hung, Kasopefoluwa Y. Oguntuyo, Christian S. Stevens, Shreyas Kowdle, Hsin-Ping Chiu, Benhur Lee, Guang-Wu Chen, Shin-Ru Shih   +24 more
doaj   +1 more source