Results 111 to 120 of about 313,654 (268)

Adaptive mutations in HA of avian H9N2 influenza viruses facilitate their transmission to swine

Veterinary Research
The cross-species transmission of avian H9N2 influenza viruses to swine increases the risk of viral adaptation to mammalian hosts. However, the mechanisms by which these H9 viruses can overcome the barriers posed by swine hosts have not yet been fully ...
Jia Wang, Peiwen Chen, Qiwei Liu, Sixia Huang, Maocai Wu, Dan’er Wei, Wenshan Hong, Tommy Tsan-Yuk Lam, Huachen Zhu, Yi Guan   +9 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Emerging infectious diseases and insensible bacillus infectious diseases. Emerging infectious diseases. Influenza virus infection diseases.

Nihon Naika Gakkai Zasshi, 1997
インフルエンザAは最も広範な流行を惹起し重症化する.今日アジア型(H2N2)の再燃や新A型ウイルスの出現が懸念されている. A型ウイルスは鳥類,ブタ,ヒトとの生活環で保持され,新型は遺伝子交雑により生ずる可能性が高い.本症のpathophysiologyが本邦を中心にin vivoで解明されつつあり,この面からのhigh risk group感染時の治療法も将来期待される.ワクチンによる予防の再評価と新抗ウイルス薬の開発も強く望まれる.
openaire   +2 more sources

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source

Patterns of genomic deletions in monkeypox virus during the 2022 outbreak in the United States

Nature Communications
Poxviruses have a low overall rate of point mutations but are known to exhibit genomic duplications and deletions that can influence viral evolution.
Crystal M. Gigante, Daisy McGrath, Sophia Sukkestad, Hui Zhao, Mengfei Peng, Jade Takakuwa, Kimberly Wilkins, Vaughn Wicker, Audrey Matheny, Theodora Khan, Whitni B. Davidson, Mili Sheth, Alex Burgin, Julie Hand, Gillian Richardson, Danielle Haydel, Mark Burroughs, Jasmine Padilla, Justin S. Lee, Dhwani Batra, Ethan E. Hetrick, Dakota T. Howard, Kyle O’Connell, Jessica L. Rowell, Shatavia Morrison, Sarah Gillani, Michelle Lee, Anil Mangla, David Blythe, Robert Myers, Lynsey Kovar, Matthew H. Seabolt, Michael R. Weigand, Panayampalli S. Satheshkumar, Andrea M. McCollum, Christina L. Hutson, Yu Li   +36 more
doaj   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source