Results 101 to 110 of about 594,203 (304)

Virus Discovery and Characterization using Next-Generation Sequencing [PDF]

, 2014
__Abstract__ Infectious diseases can be caused by a wide variety of pathogens, including viruses, bacteria, protozoa, fungi, helminths and prions. For numerous known pathogens, the disease incidence has increased over the last few decades. In addition,
Boheemen, S. (Sander) van
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mouse Model of Dengue Virus Infection with Serotypes 1 and 2 Clinical Isolates

Bio-Protocol, 2016
Dengue is a global public health threat caused by infection with any of the 4 related dengue virus serotypes (DENV1-4). Clinical manifestations range from self-limiting febrile illness, known as dengue fever (DF), to life-threatening severe diseases ...
Satoru Watanabe , Kitti Wing Chan, Subhash Vasudevan   +2 more
doaj   +1 more source

Veterinary Vaccines [PDF]

, 2007
Infectious diseases of animals are greatly increasing in importance. The rapid rise in global human population requires ever increasing production of food derived from animal agriculture and aquaculture.
Pastoret, Paul-Pierre, Roth, James, Roth, James   +2 more
core   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Integrating socio-eco-epidemiological approaches into health research [PDF]

, 2012
Sixty percent of emerging infectious diseases events are zoonotic and among those, 72% are caused by pathogens of wildlife origin. The distribution and intensity of most animal and zoonotic diseases have changed in recent years in response to ...
Gaidet, Nicolas, Molia, Sophie
core  

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Blimp-1 orchestrates macrophage polarization and metabolic homeostasis via purine biosynthesis in sepsis

Cell Death and Disease
Sepsis is a life-threatening condition characterized by a dysregulated immune response to infection, leading to systemic inflammation and organ dysfunction.
Wenjuan Peng, Qiushi Qin, Rui Li, Yujia Liu, Lan Li, Yue Zhang, Liuluan Zhu   +6 more
doaj   +1 more source

A longitudinal study of infection attack rates among hospital outpatients in Hong Kong during the epidemic of the human swine influenza A/H1N1 virus in 2009 by tracking temporal changes in age-specific seroprevalence rates [PDF]

, 2014
Poster Presentations: Emerging / Infectious Diseases: abstract no.
Chu, D, Cowling, BJ, Hung, IFN, Lau, YL, Lee, CK, Leung, G, Leung, K, Lin, CK, Lo, SV, Peiris, JSM, Perera, R, Wu, JTK   +11 more
core  

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source