Results 161 to 170 of about 21,136 (238)

Scientific research dynamics on community-acquired pneumonia: Bibliometric analysis and future perspectives. [PDF]

Medicine (Baltimore)
Dirican N, Yardibi F.
europepmc   +1 more source

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

Efficacy of a needle-free blood collection device (PIVO Pro) for avoiding contaminated blood culture sets in Australian emergency departments: protocol for an adaptive group sequential randomised controlled trial. [PDF]

BMJ Open
Lovegrove J, Valks A, Ball D, Harris PNA, Martin A, Langan G, Havers S, Vico Da Silva JJ, Keijzers G, Read B, Chan J, Furlong K, Schults J, Rickard C.   +13 more
europepmc   +1 more source

Prophylaxis Regimens for <i>Pneumocystis jirovecii</i> Pneumonia in Non-HIV, Non-Malignant Immunocompromised Adults: A Systematic Review and Network Meta-Analysis. [PDF]

J Fungi (Basel)
Wu X, Zhang Y, Wang K, Zhu L.
europepmc   +1 more source

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

Advanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

Fecal microbiota transplantation versus vancomycin or fidaxomicin in <i>Clostridioides difficile</i> infection first episode and first recurrence: a study protocol for a randomised, controlled, open-label, multicentre phase III clinical trial. [PDF]

BMJ Open
Galpérine T, Erard V, Sommerstein R, Albricht WC, Papadimitriou-Olivgeris M, Gubler M, Brugger SD, Tschudin-Sutter S, Moser M, Cagnon L, Ballif A, Becker D, Moser K, Guery B.   +13 more
europepmc   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Dengue vaccines: The role of a correlate of protection in evaluating vaccine safety and risk. [PDF]

Vaccine
Wong JM, Acevedo PK, Whitehead S, Durbin A, DeSale H, Jones FK, Medina FA, Rovira-Diaz E, Prutzman K, Leao IC, Wang T, Desilva A, Harris E, Katzelnick L, Salje H, Weiskopf D, Adams LE, Paz-Bailey G.   +17 more
europepmc   +1 more source

m5C Reader ALYREF Promotes the Progression of Endometrial Cancer by Activating the XRCC6‐Mediated Wnt/β‐catenin Signaling Pathway

Advanced Science, EarlyView.
This study identifies ALYREF as an oncogenic m5C reader in endometrial cancer. ALYREF recognizes NSUN2‐mediated m5C modification on XRCC6 mRNA to enhance transcript stability and increase XRCC6 expression. Elevated XRCC6 activates Wnt/β‐catenin signaling, resulting in accelerated tumor cell proliferation, migration, invasion, and xenograft tumor growth.
Linlin Hao, Jian Zhang, Qi Qian, Min Jiang, Yu Liu, Yan Geng, Nan Cui, Qi Guo, Jie Guo   +8 more
wiley   +1 more source