Results 1 to 10 of about 594,203 (304)

Spike-Independent Infection of Human Coronavirus 229E in Bat Cells

Microbiology Spectrum, 2023
Bats are the reservoir for numerous human pathogens, including coronaviruses. Despite many coronaviruses having descended from bat ancestors, little is known about virus-host interactions and broader evolutionary history involving bats.
Marcus G. Mah, Martin Linster, Dolyce H. W. Low, Yan Zhuang, Jayanthi Jayakumar, Firdaus Samsudin, Foong Ying Wong, Peter J. Bond, Ian H. Mendenhall, Yvonne C. F. Su, Gavin J. D. Smith   +10 more
doaj   +1 more source

Serological evidence and experimental infection of cynomolgus macaques with pteropine orthoreovirus reveal monkeys as potential hosts for transmission to humans

Emerging Microbes and Infections, 2019
Pteropine orthoreoviruses (PRV) are emerging bat-borne viruses with proven zoonotic transmission. We recently demonstrated human exposure to PRV in Singapore, which together with previous reports from Malaysia and Vietnam suggest that human infection of ...
Chee Wah Tan, Kevin Wittwer, Xiao Fang Lim, Anna Uehara, Shailendra Mani, Lin-Fa Wang, Danielle E. Anderson   +6 more
doaj   +1 more source

High flavivirus structural plasticity demonstrated by a non-spherical morphological variant

Nature Communications, 2020
Dengue (DENV) and Zika (ZIKV) viruses normally display as smooth spherical particles, while DENV can also become bumpy-surfaced, resulting in immune evasion. Here, Morrone et al. report DENV and ZIKV infectious club-shaped particles (clubSP) that display
Seamus R. Morrone, Valerie S. Y. Chew, Xin-Ni Lim, Thiam-Seng Ng, Victor A. Kostyuchenko, Shuijun Zhang, Melissa Wirawan, Pau-Ling Chew, Jaime Lee, Joanne L. Tan, Jiaqi Wang, Ter Yong Tan, Jian Shi, Gavin Screaton, Marc C. Morais, Shee-Mei Lok   +15 more
doaj   +1 more source

Dengue virus activates cGAS through the release of mitochondrial DNA

Scientific Reports, 2017
Cyclic GMP-AMP synthetase (cGAS) is a DNA-specific cytosolic sensor, which detects and initiates host defense responses against microbial DNA. It is thus curious that a recent study identified cGAS as playing important roles in inhibiting positive-sense ...
Bo Sun, Karin B. Sundström, Jun Jie Chew, Pradeep Bist, Esther S. Gan, Hwee Cheng Tan, Kenneth C. Goh, Tanu Chawla, Choon Kit Tang, Eng Eong Ooi   +9 more
doaj   +1 more source

SARS-CoV-2 genomic and subgenomic RNAs in diagnostic samples are not an indicator of active replication

Nature Communications, 2020
During SARS-CoV-2 replication subgenomic RNAs (sgRNA) are transcribed and subsequently translated into viral proteins. Here, Alexandersen et al. provide evidence that sgRNA is not necessarily an indicator for active viral replication, but can be detected
Soren Alexandersen, Anthony Chamings, Tarka Raj Bhatta   +2 more
doaj   +1 more source

Serological differentiation between COVID-19 and SARS infections

Emerging Microbes and Infections, 2020
In response to the coronavirus disease 2019 (COVID-19) outbreak, caused by SARS-CoV-2, multiple diagnostic tests are required for acute disease diagnosis, contact tracing, monitoring asymptomatic infection rates and assessing herd immunity.
Wan Ni Chia, Chee Wah Tan, Randy Foo, Adrian Eng Zheng Kang, Yilong Peng, Velraj Sivalingam, Charles Tiu, Xin Mei Ong, Feng Zhu, Barnaby E. Young, Mark I.-C. Chen, Yee-Joo Tan, David C. Lye, Danielle E. Anderson, Lin-Fa Wang   +14 more
doaj   +1 more source

Self-disseminating vaccines for emerging infectious diseases. [PDF]

, 2015
Modern human activity fueled by economic development is profoundly altering our relationship with microorganisms. This altered interaction with microbes is believed to be the major driving force behind the increased rate of emerging infectious diseases ...
Jarvis, MA, Murphy, AA, Redwood, AJ
core   +2 more sources

Emerging infectious diseases [PDF]

Journal of Clinical Investigation, 2004
Human population growth, technological advances, and changing social behaviors lead to the selection of new microbial pathogens. Antimicrobial drugs, vaccines, diagnostics, and treatments for emerging infectious diseases must be developed. The selective forces that drive the emergence of new infectious diseases, and the implications for our survival ...
openaire   +2 more sources

Understanding the failure of a behavior change intervention to reduce risk behaviors for avian influenza transmission among backyard poultry raisers in rural Bangladesh: a focused ethnography

BMC Public Health, 2016
Background The spread of the highly pathogenic avian influenza (HPAI) H5N1 virus among poultry and humans has raised global concerns and has motivated government and public health organizations to initiate interventions to prevent the transmission of ...
Nadia Ali Rimi, Rebeca Sultana, Kazi Ishtiak-Ahmed, Md Zahidur Rahman, Marufa Hasin, M. Saiful Islam, Eduardo Azziz-Baumgartner, Nazmun Nahar, Emily S. Gurley, Stephen P. Luby   +9 more
doaj   +1 more source

Attenuated dengue viruses are genetically more diverse than their respective wild-type parents

npj Vaccines, 2021
Dengue poses a significant burden of individual health, health systems and the economy in dengue endemic regions. As such, dengue vaccine development has been an active area of research.
Amanda Makha Bifani, Milly M. Choy, Hwee Cheng Tan, Eng Eong Ooi   +3 more
doaj   +1 more source