Results 121 to 130 of about 1,816,741 (301)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Lessons Learned in a Math Excel Workshop: The Importance of Maintaining High Cognitive Demands [PDF]
, 2003 Uri Treisman\u27s Emerging Scholars Workshop model has been implemented on many college campuses over the last twenty years. The Treisman model is based on groups of students meeting regularly in a social atmosphere to work collaboratively in solving ...
Dick, T.
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Design Research and Domain Representation [PDF]
, 2009 While diverse theories about the nature of design research have been proposed, they are rarely considered in relation to one another across the broader disciplinary field.
Joseph, Frances
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
RESEARCH ETHICS IN EMERGENCY MEDICINE
Emergency Medicine Clinics of North America, 1999 A framework for the ethical conduct of research is constructed within this article. The historical developments and current state of ethical principles and regulations guiding ethical conduct of research are reviewed, while situations unique to emergency medicine research are highlighted.
openaire +2 more sources
New Association of Counsellors Annual Research Conference 2017 [PDF]
, 2017 An annual conference for established counsellor researchers and emerging researchers to present their work to colleagues and attain ...
Crocket, Alastair +2 more
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
International Journal of Behavioral Nutrition and Physical ActivityBackground Life satisfaction is a key indicator of quality of life among older adults. This systematic review and meta-analysis synthesised evidence on the association between life satisfaction and health behaviours such as smoking status, alcohol use ...
Chiedozie James Alumona +8 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source