Results 101 to 110 of about 1,816,741 (301)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
BMJ OpenIntroduction Life satisfaction is a key indicator of successful ageing and reflects well-being. There is evidence of the association between life satisfaction and health behaviours among older adults.
Michael Kalu +5 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
MatchZoo: A Learning, Practicing, and Developing System for Neural Text Matching
, 2019 Text matching is the core problem in many natural language processing (NLP) tasks, such as information retrieval, question answering, and conversation.
Cheng, Xueqi +3 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Editorial: Research Groups and Individual Scholarship
Issues and Trends in Educational Technology, 2015 Exciting new research is emerging from Educational Techology research groups. Individual researchers are invited to consider their own scholarship in light of these groups’ work.
Betül Czerkawski, Eugene Lyman
doaj +2 more sources
Who’s counting? Measuring social outcomes from targeted private equity [PDF]
The potential of private equity investment in emerging domestic markets to deliver strong financial returns while also giving rise to public benefits has drawn the attention of both venture and economic development capital, as well as policymakers and ...
Janneke Ratcliffe
core
Missing Women and Bare Branches: Gender Balance and Conflict [PDF]
, 2005 The emerging subfield of “security demographics” examines the linkages between population dynamics and the security trajectories of nation-states.
den Boer, Andrea, Hudson, Valerie M
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source