Results 91 to 100 of about 3,868,080 (298)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Sudanese Researchers Scholarships Guide

, 2020
The first edition of the Sudanese Researchers Scholarships Guide is a comprehensive resource for university scholarship programs that are available or targeted to Sudanese students.The Guide covers different types of scholarships, principles of ...
Sudanese Researchers Foundation (8632581)
core   +1 more source

Community Roles for Supporting Emerging Education Researchers [PDF]

, 2021
DBER attracts many faculty from other STEM disciplines, and these faculty have little or no specific training in DBER. DBER requires a mastery of quantitative, qualitative, and/or mixed methodologies, and also a nuanced understanding of breadth of topic,
Hancock, Emilie, Wilson, Samantha, Hass, Christopher A. F., El-Adawy, Shams, Sayre, Eleanor C.   +4 more
core  

Building consensus on priority areas for Sub-Saharan Africa's ageing population research: An e-Delphi study protocol.

PLoS ONE
BackgroundImprovement in medico-social services has increased life expectancy and population ageing in Sub-Saharan Africa (SSA). It was estimated that about 163 million people aged 65 and older will be resident in SSA by 2050.
Augustine Chukwuebuka Okoh, Ogochukwu Kelechi Onyeso, Wendy Ekemezie, Oluwagbemiga Oyinlola, Olayinka Akinrolie, Michael Kalu, Emerging Researchers & Professionals in Ageing-African Network   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Seeing the human behind the research: Strengthening emerging African disability researchers

African Journal of Disability
Background: A pre-conference workshop that investigated the experiences and needs of PhD candidates and early career researchers in disability studies in Africa was held as part of the proceedings of the African Network for Evidence to Action in ...
Michelle Botha, Chioma Ohajunwa
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Unequal Foundations: Publishing Challenges for Emerging Researchers in Sub-Saharan Africa

Trends in Scholarly Publishing
Early-career researchers in Sub-Saharan Africa face persistent structural and historical inequities in academic publishing, including inadequate funding, limited mentorship, language barriers, and restricted access to scholarly resources.
Aisha Abdullahi Mahmud, Ibrahim Gambo, Abdulrahman Mahmud Dogara, Muhammad Abubakar Adam   +3 more
doaj   +1 more source