Results 151 to 160 of about 1,792,929 (311)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

BIOTECHNOLOGY, A FARMER'S PERSPECTIVE [PDF]

Research and Development/Tech Change/Emerging Technologies,
Boisen, Douglas D.
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

The Future of Epigenetics: Emerging Technologies and Clinical Applications. [PDF]

ACS Pharmacol Transl Sci
Iyer KA, Koynova-Tenchov R, Sasso JM, Thite T, Deng Y, Zhou QA.   +5 more
europepmc   +1 more source

THE SYSTEMS APPROACH -- RESEARCH OR RESEARCH MANAGEMENT [PDF]

Research and Development/Tech Change/Emerging Technologies,
Parvin, David W., Jr., Tyner, Fred H.
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Synergistic Integration of Liposomes with Emerging Technologies for Food Applications. [PDF]

Molecules
Varas Condori MA, Ibáñez Bendezú A, Romero J, Villasante A, Opazo R, Cordero-Machuca J, Muñoz-Shugulí C, Patiño Vidal C, Andrade-Pizarro R, López-Polo J.   +9 more
europepmc   +1 more source

Spillovers, Joint Ventures and Social Welfare in a Mixed Duopoly R&D Race [PDF]

Research and Development/Tech Change/Emerging Technologies,
Naseem, Anwar, Oehmke, James F.
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Systematic review of emerging technologies in vascularized composite allotransplantation. [PDF]

Front Transplant
Chakradhar A, Yu M, Talbot SG.
europepmc   +1 more source