Results 21 to 30 of about 1,792,929 (311)

The cardiotropic properties of ZMEI-3 compound – a potential inhibitor of Epac proteins

Фармакокинетика и Фармакодинамика
Introduction. It is known that the allosteric effector of cAMP, in addition to protein kinase A, is the Epac regulatory proteins, which in cardiomyocytes play a key role in the electromechanical coupling control and their rhythmic activity.
S. A. Kryzhanovskii, G. V. Mokrov, I. B. Tsorin, E. O. Ionova, M. B. Vititnova, V. N. Stolyaruk, I. A. Miroshkina, A. V. Sorokina, A. D. Durnev   +8 more
doaj   +1 more source

Anticancer activity of tyrosine kinase TrkA receptors antagonist GK-1 in experiment on mice with mammary gland adenocarcinoma Ca755

Фармакокинетика и Фармакодинамика
The aim of this study was to evaluate the effect of original tyrosine kinase TrkA antagonist GK-1 on tumor growth, median lifespan and hematological parameters in experiment on female mice C57Bl/6 with mammary gland adenocarcinoma Ca755.
L. P. Kovalenko, P. Yu. Povarnina, R. V. Zhurikov, S. V. Alekseeva, L. G. Kolik, T. A. Gudasheva, A. D. Durnev, V. I. Dorofeev   +7 more
doaj   +1 more source

Bidirectional nuclear polarization through electric dipole spin resonance enabled by spin-orbit interaction in a single hole planar quantum dot device

npj Quantum Information
Spin exchange between confined holes and nuclei has been demonstrated for zero-dimensional quantum dots by optical techniques but has not been observed for gated planar structures.
Sergei Studenikin, Jordan Ducatel, Olivia Ellis, Marek Korkusinski, Alex Bogan, Piotr Zawadzki, D. Guy Austing, Andrew Sachrajda   +7 more
doaj   +1 more source

Acute toxicity study of a new dibenzofuran oxime derivative GIZH-272 in mice

Фармакокинетика и Фармакодинамика
Relevance. Acute toxicity testing is a common procedure for preclinical safety testing of potential agents. The purpose of this study was to study the acute toxicity of the compound GIZH-272, a new dibenzofuran oxime derivative with anti-ischemic and ...
S. V. Alekseeva, A. V. Sorokina, A. V. . Volkova, I. A. Miroshkina, K. S. Kachalov, I. V. Alekseev, A. D. Zakharov, A. D. Durnev   +7 more
doaj   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Synthesis and the antidepressant-like activity investigation of bis-(N-monosuccinyl-D-seryl-D-lysine) hexamethylenediamide, the DD-enantiomer of the BDNF dipeptide mimetic, compound GSB-106

Фармакокинетика и Фармакодинамика
Previously, based on the β-turn of the fourth loop of the brain-derived neurotrophic factor, we obtained GSB-106 (bis-(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide), that has pronounced neuroprotective and antidepressant activities in doses of 0.
N. M. Sazonova, A. V. Tarasyuk, M. Yu. Filippova, M. V. Melnikova, D. M. Nikiforov, P. Yu. Povarnina, T. A. Gudasheva, V. L. Dorofeev   +7 more
doaj   +1 more source

Pediatric Oncology Nursing Competencies in Latin America and the Caribbean: A Scoping Review to Inform Practice, Education, and Research

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Nurses are central to cancer care for children and adolescents, yet no comprehensive synthesis has defined essential core competencies for pediatric oncology nursing (PON) practice internationally, particularly in Latin America and the Caribbean (LAC).
Luís Carlos Lopes‐Júnior, Edmara Bazoni Soares Maia, Soad Fuentes‐Alabí, Courtney E. Sullivan, Monnie Abraham, Mauricio Maza, Liliana Vásquez Ponce, Regina Aparecida Garcia Lima   +7 more
wiley   +1 more source

Pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GK-2 in rats. Part 2. Kinetics of distribution in organs and tissues

Фармакокинетика и Фармакодинамика
Relevance. To introduce the GK-2 compound into clinical practice, it is necessary to conduct a preclinical study of its pharmacokinetics, in particular, the distribution of the studied drug in organs and tissues.
G. B. Kolyvanov, A. A. Litvin, P. O. Bochkov, O. Yu. Kravtsova, O. G. Gribakina, P. Yu. Povarnina, V. P. Zherdev   +6 more
doaj   +1 more source

Control of the stochastic response of magnetization dynamics in spin-torque oscillator through radio-frequency magnetic fields

Scientific Reports, 2021
Neuromorphic computing using spintronic devices, such as spin-torque oscillators (STOs), has been intensively studied for energy-efficient data processing.
Sumito Tsunegi, Tomohiro Taniguchi, Daiki Suzuki, Kay Yakushiji, Akio Fukushima, Shinji Yuasa, Hitoshi Kubota   +6 more
doaj   +1 more source

Research Trends & Emerging Technologies for Genealogists [PDF]

, 2016
This study examines current research methods utilized by genealogists, and seeks to discover the impact of emerging tools and technologies on their information seeking needs and behaviors.
Lucy, Catherine
core   +1 more source