Results 31 to 40 of about 7,314,464 (305)

Synthesis and the antidepressant-like activity investigation of bis-(N-monosuccinyl-D-seryl-D-lysine) hexamethylenediamide, the DD-enantiomer of the BDNF dipeptide mimetic, compound GSB-106

Фармакокинетика и Фармакодинамика
Previously, based on the β-turn of the fourth loop of the brain-derived neurotrophic factor, we obtained GSB-106 (bis-(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide), that has pronounced neuroprotective and antidepressant activities in doses of 0.
N. M. Sazonova, A. V. Tarasyuk, M. Yu. Filippova, M. V. Melnikova, D. M. Nikiforov, P. Yu. Povarnina, T. A. Gudasheva, V. L. Dorofeev   +7 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GK-2 in rats. Part 2. Kinetics of distribution in organs and tissues

Фармакокинетика и Фармакодинамика
Relevance. To introduce the GK-2 compound into clinical practice, it is necessary to conduct a preclinical study of its pharmacokinetics, in particular, the distribution of the studied drug in organs and tissues.
G. B. Kolyvanov, A. A. Litvin, P. O. Bochkov, O. Yu. Kravtsova, O. G. Gribakina, P. Yu. Povarnina, V. P. Zherdev   +6 more
doaj   +1 more source

Materials and challenges of 3D printing of emerging memory devices

Memories - Materials, Devices, Circuits and Systems, 2023
The continuous development of the semiconductor industry to meet the increasing demand of modern electronic devices which can enhance computing capabilities is attributed to the exploration of efficient, simple, high-speed operation and multistate ...
Iulia Salaoru, Swapnodoot Ganguly, Dave Morris, Shashi Paul   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Wafer‐Scale Atomically‐Thin Gold: Transferable Platform for Flexible Optoelectronics, Thermal Management and Bio‐Interfaces

Advanced Science
The integration of metals into two‐dimensional material architectures is essential for next‐generation electronics, but their high surface energy intrinsically favors three‐dimensional island growth, hindering the scalable fabrication of continuous ...
Dmitry Yakubovsky, Mikhail Mironov, Georgy Ermolaev, Aleksandr Khrebtov, Aleksandr Slavich, Prashant Narute, Pritom Chowdhury, Roman Kirtaev, Igor Khramtsov, Anton Minnekhanov, Gleb Tselikov, Dmitriy Grudinin, Maria Sidorova, Nikolay Pak, Pavel Maslov, Andrey Vyshnevyy, Hongkai Zhou, Vasyl G. Kravets, Alexander N. Grigorenko, Ivan Kruglov, Nikita Orekhov, Dmitry Kireev, Aleksey Arsenin, Kostya S. Novoselov, Valentyn Volkov   +24 more
doaj   +1 more source

“Holiday heart” syndrome in rats: Features of microcirculation, functional state and anatomy of the heart

Фармакокинетика и Фармакодинамика
Purpose of the study. Studying the features of microcirculation, functional state and anatomy of the heart using the “Holiday Heart” syndrome model in rats we developed.Materials and methods. Experiments were carried out on white outbred male rats.
S. A. Kryzhanovskii, I. B. Tsorin, E. O. Ionova, M. B. Vititnova, S. A. Simonenko, L. G. Kolik   +5 more
doaj   +1 more source

Giant charge-to-spin conversion in ferromagnet via spin-orbit coupling

Nature Communications, 2021
Geometrical restriction is a serious obstacle for electrical manipulation of magnetism using the spin Hall effect. Here, Hibino et al. report a mechanism of magnetic-dependent charge-to-spin conversion in a ferromagnet due to spin-orbit coupling, which ...
Yuki Hibino, Tomohiro Taniguchi, Kay Yakushiji, Akio Fukushima, Hitoshi Kubota, Shinji Yuasa   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Involvement of TRK receptors in the nootropic effect of cycloprolylglycine

Фармакокинетика и Фармакодинамика
Background. The neuropeptide cycloprolylglycine (CPG) is an endogenous dipeptide analogue of the nootropic piracetam. It has been experimentally shown that CPG (designed and synthesized at the Federal State Budgetary Scientific Institution «Federal ...
O. N. Vorontsova, A. G. Alyaeva, K. N. Koliasnikova, P. Yu. Povarnina, T. A. Gudasheva, V. L. Dorofeev   +5 more
doaj   +1 more source