Results 51 to 60 of about 1,792,929 (311)

Blood microcirculation under conditions of a translational model of alcohol cardiomyopathy in rats

Фармакокинетика и Фармакодинамика
Purpose of the study. Studying the blood microcirculation characteristics in the brain and heart of rats with ACM.Materials and methods. The study was carried out on white outbred male rats.
S. A. Kryzhanovskii, I. B. Tsorin, E. O. Ionova, S. A. Simonenko, M. B. Vititnova   +4 more
doaj   +1 more source

Exploring emerging technologies for extreme scale HPC architectures [PDF]

, 2016
While architectures and programming models have remained relatively stable for almost two decades, new architectural features, such as heterogeneous processing, nonvolatile memory, and optical interconnection networks, will demand that software systems ...
Vetter, Jeffery S.
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Pharmacokinetics of a potential antiepileptic drug GIZh-298

Фармакокинетика и Фармакодинамика
GIZh-298 pharmacokinetics was studied in rats after different dosage regimens.The aim of this study was to study GIZh-298 pharmacokinetics after its multiple intragastric administration.Methods. The study was conducted on outbred male rats.
G. B. Kolyvanov, A. A. Litvin, O. Yu. Kravtsova, O. G. Gribakina, V. P. Zherdev   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Exploring van der Waals materials with high anisotropy: geometrical and optical approaches

Light: Science & Applications
The emergence of van der Waals (vdW) materials resulted in the discovery of their high optical, mechanical, and electronic anisotropic properties, immediately enabling countless novel phenomena and applications.
Aleksandr S. Slavich, Georgy A. Ermolaev, Mikhail K. Tatmyshevskiy, Adilet N. Toksumakov, Olga G. Matveeva, Dmitriy V. Grudinin, Kirill V. Voronin, Arslan Mazitov, Konstantin V. Kravtsov, Alexander V. Syuy, Dmitry M. Tsymbarenko, Mikhail S. Mironov, Sergey M. Novikov, Ivan Kruglov, Davit A. Ghazaryan, Andrey A. Vyshnevyy, Aleksey V. Arsenin, Valentyn S. Volkov, Kostya S. Novoselov   +18 more
doaj   +1 more source

Dimeric dipeptide mimetics of BDNF loop 4 are potential antidepressants with novel mechanisms of action

Фармакокинетика и Фармакодинамика
This review covers original research focused on the design, synthesis, and pharmacological evaluation of an innovative dimeric dipeptide mimetic of brain-derived neurotrophic factor (BDNF) loop 4 bis-(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide
T. A. Gudasheva, P. Yu. Povarnina, A. V. Tarasyuk, V. P. Zherdev, A. D. Durnev   +4 more
doaj   +1 more source

Carbon-Nanotube Based Thermoelectrical Paste for Enhancing Solar Cell Effciency

E3S Web of Conferences, 2018
A super-passive cooling technique based on a thermal paste is proposed for PV efficiency enhancement in elevated temperature conditions. A mixture between carbon nanotubes and graphene having a promising Seebeck coefficient is chosen.
Mohamed Fathi Sanad, Ahmed Shaker, Sameh O. Abdellatif, Iman Elmahallawi, Hani A. Ghali, Khaled Kirah   +5 more
doaj   +1 more source

Emerging technology and techniques

Indian Journal of Dental Research, 2015
A technique of fabricating feldspathic porcelain pressable ingots was proposed. A 5 ml disposable syringe was used to condense the powder slurry. The condensed porcelain was sintered at 900΀C to produce porcelain ingots. The fabricated porcelain ingots were used in pressable ceramic machines. The technological advantages of pressable system improve the
Gopi Naveen Chander, B Mutukumar, C Sasikala, N Dhanasekar   +3 more
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source