Results 61 to 70 of about 1,792,929 (311)

Multifunctional van der Waals PdSe2 for light detection, guiding and modulation

Nature Communications
Modern optoelectronic devices demand materials that can perform multiple, often conflicting functions, such as acting as metals for interconnects, dielectrics for waveguides, and semiconductors for light emission and detection.
Aleksandr Slavich, Georgy Ermolaev, Nikolay Pak, Dmitriy Grudinin, Konstantin Kravtsov, Mikhail Tatmyshevskiy, Valentin Semkin, Alexander Syuy, Arslan Mazitov, Anton Minnekhanov, Ivan Kazantsev, Dmitriy Dyubo, Amir Eghbali, Dmitry Yakubovsky, Mikhail Kashchenko, Mikhail Podobrii, Elena Titova, Alexander Melentev, Elena Zhukova, Gleb Tselikov, Ivan Kruglov, Dmitry Svintsov, Sergey Novikov, Andrey Vyshnevyy, Aleksey Arsenin, Kostya S. Novoselov, Valentyn Volkov   +26 more
doaj   +1 more source

The study of antiparkinsonian activity of the combination of ladasten with fabomotizole in paraquat-induced model of parkinsoian syndrome

Фармакокинетика и Фармакодинамика
Relevance. Parkinson's disease (PD) is a neurodegenerative disease characterized by motor impairments. The currently used antiparkinsonian pharmacotherapy, despite the symptomatic improvement of patients, is associated with severe side effects.
V. E. Marievskii, İ. A. Lyubanskii, S. V. Shangin, L. F. Zainullina, V. L. Dorofeev   +4 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Enhancing the environmental sustainability of IT [PDF]

, 2009
Emerging technologies for learning report - Article exploring green ...
Ohara, Dave, Steven, Anthony
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Experimental pharmacokinetics of a new antiparkinsonian drug ADK-1113

Фармакокинетика и Фармакодинамика
The pharmacokinetics of a new antiparkinsonian drug ADK-1113 after single intravenous and intragastric administrations in mice at doses of 10 and 20 mg/kg was studied.
O. Yu. Kravtsova, D. A. Dvoryaninov, G. B. Kolyvanov, A. A. Litvin, O. G. Gribakina, V. P. Zherdev   +5 more
doaj   +1 more source

Emerging aerospace technologies [PDF]

The United States Government has a long history of promoting the advancement of technology to strengthen the economy and national defense. An example is NASA, which was formed in 1958 to establish and maintain U.S. space technology leadership.
Ballhaus, W. F., Jr., Milov, L. A.
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Analysis of original bis-arylazaazkanes derivatives compliance with the calculated pharmacophoric models of biaromatic ligands of cardioprotective drugs biotargets

Фармакокинетика и Фармакодинамика
Eight important biotargets of biaromatic cardioprotective drugs were selected in this work: calcium Cav1.2-channel, sodium Nav1.5-channel, potassium hERG-channel and Kv1.5-channel, HCN-channel, β1-adrenergic receptor, ryanodine RyR2-receptor and σ1 ...
G. V. Mokrov, A. S. Pantileev, T. Yu. Vorobieva, V. E. Biryukova, S. A. Kryzhanovskii, V. L. Dorofeev   +5 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source