Results 61 to 70 of about 7,314,464 (305)

Emerging graphene device technologies

open access: yes, 2016
Graphene has a wide range of attractive electrical and mechanical properties. This unique blend of properties make it a good candidate for emerging and future device technologies, such as sensors, high frequency electronics, and energy storage devices ...
Li, Jiantong,   +5 more
core   +1 more source

Multifunctional van der Waals PdSe2 for light detection, guiding and modulation

open access: yesNature Communications
Modern optoelectronic devices demand materials that can perform multiple, often conflicting functions, such as acting as metals for interconnects, dielectrics for waveguides, and semiconductors for light emission and detection.
Aleksandr Slavich   +26 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Experimental pharmacokinetics of a new antiparkinsonian drug ADK-1113

open access: yesФармакокинетика и Фармакодинамика
The pharmacokinetics of a new antiparkinsonian drug ADK-1113 after single intravenous and intragastric administrations in mice at doses of 10 and 20 mg/kg was studied.
O. Yu. Kravtsova   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Adding critical sensibilities to domestic communication technologies [PDF]

open access: yes, 2009
This paper presents suggestions for a more pragmatic approach to the design of emerging and future domestic communication technologies, particularly technologies destined for the home that maybe deemed ‘ubiquitous’. This is achieved through two critical
Bonner, John V H, Bonner, John V.H.
core   +1 more source

Analysis of original bis-arylazaazkanes derivatives compliance with the calculated pharmacophoric models of biaromatic ligands of cardioprotective drugs biotargets

open access: yesФармакокинетика и Фармакодинамика
Eight important biotargets of biaromatic cardioprotective drugs were selected in this work: calcium Cav1.2-channel, sodium Nav1.5-channel, potassium hERG-channel and Kv1.5-channel, HCN-channel, β1-adrenergic receptor, ryanodine RyR2-receptor and σ1 ...
G. V. Mokrov   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Nanoprinting organic molecules at the quantum level

open access: yesNature Communications, 2019
Integration of emitters for nanophotonic applications requires precise control over their position and orientation. Here, Hail et al. demonstrate the positioning of a single and a small number of oriented molecules with subwavelength accuracy bu direct ...
Claudio U. Hail   +7 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

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